Jiang, HaijingLi, JunYu, KuaiYang, HandongMin, XinwenChen, HuanqianWu, Tangchun2017-12-052017Jiang, Haijing, Jun Li, Kuai Yu, Handong Yang, Xinwen Min, Huanqian Chen, and Tangchun Wu. 2017. “Associations of estimated glomerular filtration rate and blood urea nitrogen with incident coronary heart disease: the Dongfeng-Tongji Cohort Study.” Scientific Reports 7 (1): 9987. doi:10.1038/s41598-017-09591-6. http://dx.doi.org/10.1038/s41598-017-09591-6.http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492110Estimated glomerular filtration rate (eGFR) has been reported to be associated with risk of incident coronary heart disease (CHD), and blood urea nitrogen (BUN) has been shown to be a strong predictor of mortality in patients with heart failure (HF). However, such epidemiological evidence from Chinese population was still limited. We used Cox proportional-hazards regression models to investigate the associations of eGFR and BUN with risk of incident CHD in the prospective Dongfeng-Tongji (DFTJ) cohort. After fully adjusted for potential confounders, a 10-unit decline in eGFR was associated with higher risk for CHD (hazard ratio [HR] 1.05, 95% confidence interval [CI] 1.01–1.09); compared with individuals with normal eGFR levels (eGFR ≥ 90 ml/min per 1.73 m2), individuals with a mild-to-severe eGFR decline (15 to 60 ml/min per 1.73 m2) were at significantly greater risk for CHD (HR 1.25, 95% CI 1.05–1.48; P = 0.011). Compared with individuals in the lowest tertile of BUN, those in the highest tertile were at significantly greater risk for CHD (HR 1.17, 95% CI 1.03–1.33; P = 0.014). In conclusion, a mild-to-severe decline in eGFR or a raised level of BUN might be associated with increased risk of incident CHD in middle-aged and elderly Chinese populations.en-USJournal Article2017-12-0510.1038/s41598-017-09591-6