Bernatsky, SashaVelásquez García, Héctor ASpinelli, John JGaffney, PatrickSmedby, Karin ERamsey-Goldman, RosalindWang, Sophia SAdami, Hans-OlovAlbanes, DemetriusAngelucci, EmanueleAnsell, Stephen MAsmann, Yan WBecker, NikolausBenavente, YolandaBerndt, Sonja IBertrand, Kimberly ABirmann, BrendaBoeing, HeinerBoffetta, PaoloBracci, Paige MBrennan, PaulBrooks-Wilson, Angela RCerhan, James RChanock, Stephen JClavel, JacquelineConde, LuciaCotenbader, Karen HCox, David GCozen, WendyCrouch, SimonDe Roos, Anneclaire Jde Sanjose, SilviaDi Lollo, SimonettaDiver, W RyanDogan, AhmetForetova, LenkaGhesquières, HervéGiles, Graham GGlimelius, BengtHabermann, Thomas MHaioun, CorinneHartge, PatriciaHjalgrim, HenrikHolford, Theodore RHolly, Elizabeth AJackson, Rebecca DKaaks, RudolphKane, EleanorKelly, RachelKlein, Robert JKraft, PhillipKricker, AnneLan, QingLawrence, CharlesLiebow, MarkLightfoot, TracyLink, Brian KMaynadie, MarcMcKay, JamesMelbye, MadsMolina, Thierry JMonnereau, AlainMorton, Lindsay MNieters, AlexandraNorth, Kari ENovak, Anne JOffit, KennethPurdue, Mark PRais, MarcoRiby, JacquesRoman, EveRothman, NathanielSalles, GillesSeveri, GianlucaSeverson, Richard KSkibola, Christine FSlager, Susan LSmith, AlexSmith, Martyn TSouthey, Melissa CStaines, AnthonyTeras, Lauren RThompson, Carrie ATilly, HervéTinker, Lesley FTjonneland, AnneTurner, JennyVajdic, Claire MVermeulen, Roel C HVijai, JosephVineis, PaoloVirtamo, JarmoWang, ZhaomingWeinstein, StephanieWitzig, Thomas EZelenetz, AndrewZeleniuch-Jacquotte, AnneZhang, YaweiZheng, TongzhangZucca, MariagraziaClarke, Ann E2018-01-182017Bernatsky, S., H. A. Velásquez García, J. J. Spinelli, P. Gaffney, K. E. Smedby, R. Ramsey-Goldman, S. S. Wang, et al. 2017. “Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma.” Lupus Science & Medicine 4 (1): e000187. doi:10.1136/lupus-2016-000187. http://dx.doi.org/10.1136/lupus-2016-000187.http://nrs.harvard.edu/urn-3:HUL.InstRepos:34651971Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.en-USlymphomaSystemic lupusmalignancyJournal Article2018-01-1810.1136/lupus-2016-000187