Alvarez, Mario M.Aizenberg, JoannaAnaloui, MostafaAndrews, Anne M.Bisker, GiliBoyden, Edward S.Kamm, Roger D.Karp, JeffreyMooney, DavidOklu, RahmiPeer, DanStolzoff, MichelleStrano, Michael S.Trujillo-de Santiago, GrisselWebster, Thomas J.Weiss, PaulKhademhosseini, Ali2018-07-172017Alvarez, Mario M., Joanna Aizenberg, Mostafa Analoui, Anne M. Andrews, Gili Bisker, Edward S. Boyden, Roger D. Kamm, et al. 2017. “Emerging Trends in Micro- and Nanoscale Technologies in Medicine: From Basic Discoveries to Translation.” ACS Nano 11 (6) (May 19): 5195–5214. doi:10.1021/acsnano.7b01493.1936-0851http://nrs.harvard.edu/urn-3:HUL.InstRepos:37251600We discuss the state of the art and innovative micro- and nano- scale technologies that are finding niches and opening up new opportunities in medicine, particularly in diagnostic and therapeutic applications. We take the design of point-of-care applications and the capture of circulating tumor cells as illustrative examples of the integration of micro- and nanotechnologies into solutions of diagnostic challenges. We describe several novel nanotechnologies that enable imaging cellular structures and molecular events. In therapeutics, we describe the utilization of micro- and nanotechnologies in applications including drug delivery, tissue engineering, and pharmaceutical development/testing. In addition, we discuss relevant challenges that micro- and nanotechnologies face in achieving cost-effective and widespread clinical implementation as well as forecasted applications of micro- and nanotechnologies in medicine.en-USJournal Article2018-07-15201710.1021/acsnano.7b01493