Shen, ShiqianLim, GrewoYou, ZerongDing, WeihuaHuang, PeigenRan, ChongzhaoDoheny, JasonCaravan, PeterTate, SamuelHu, KunKim, HyanginMcCabe, MichaelHuang, BoXie, ZhongcongKwon, DouglasChen, LucyMao, Jianren2018-02-262017Shen, S., G. Lim, Z. You, W. Ding, P. Huang, C. Ran, J. Doheny, et al. 2017. “Gut Microbiota is critical for the induction of chemotherapy-induced pain.” Nature neuroscience 20 (9): 1213-1216. doi:10.1038/nn.4606. http://dx.doi.org/10.1038/nn.4606.http://nrs.harvard.edu/urn-3:HUL.InstRepos:34868844Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients undergoing chemotherapy. We found that the gut microbiota promotes the development of chemotherapy-induced mechanical hyperalgesia. Oxaliplatin-induced mechnical hyperalgesia was reduced in germ-free mice and in those mice pretreated with antibiotics. Restoration of the microbiota of germ-free mice abrogated this protection. These effects appear to be mediated, in part, by TLR4 expressed on hematopoietic cells, including macrophages.en-USJournal Article2018-02-2610.1038/nn.4606