James-Todd, TamarraMarch, Melissa I.Seiglie, JacquelineGupta, MunishBrown, Florence M.Majzoub, Joseph A.2018-07-252017James-Todd, Tamarra, Melissa I. March, Jacqueline Seiglie, Munish Gupta, Florence M. Brown, and Joseph A. Majzoub. 2017. “Racial Differences in Neonatal Hypoglycemia among Very Early Preterm Births.” Journal of perinatology : official journal of the California Perinatal Association 38 (3): 258-263. doi:10.1038/s41372-017-0003-9. http://dx.doi.org/10.1038/s41372-017-0003-9.http://nrs.harvard.edu/urn-3:HUL.InstRepos:37298449Objective: To determine whether the prevalence of neonatal hypoglycemia differs by race/ethnicity. Study Design A retrospective cohort study using prospectively collected data from 515 neonates born very preterm (<32 weeks) to normoglycemic women and admitted to the neonatal intensive care unit (NICU) at a major tertiary hospital in Boston, MA between 2008 and 2012. Results: A total of 61%, 12%, 7%, 7%, and 13% were White, Black, Hispanic, Asian, and Other, respectively. Among the 66% spontaneous preterm births, 63% of the black neonates experienced hypoglycemia (blood glucose level<40 mg/dL), while only 22–30% of the other racial/ethnic neonates did so (Black v. White RR 2.15; 95% CI: 1.54–3.00). After adjusting for maternal education, maternal age, multiple gestations, delivery type, gestational age, birth weight and neonates’ sex, this association remained significant (adjusted Black v. White RR: 1.61, 95% CI: 1.13–2.29). An increased risk of infant hypoglycemia was not seen in infants of other racial/ethnic groups, nor in any racial/ethnic group with a medically-indicated preterm birth. Conclusions: Black neonates delivered for spontaneous (but not medical) indications at <32 weeks had a higher risk of hypoglycemia, which could provide critical information about mechanisms of preterm birth and adverse postnatal outcomes in this high-risk group.en-USracedisparitypreterm birthhypoglycemianeonatalJournal Article2018-07-2510.1038/s41372-017-0003-9