Anderson, Stacey M.Raghinaru, DanPinsker, Jordan E.Boscari, FedericoRenard, EricBuckingham, Bruce A.Nimri, RevitalDoyle, FrancisBrown, Sue A.Keith-Hynes, PatrickBreton, Marc D.Chernavvsky, DanielBevier, Wendy C.Bradley, Paige K.Bruttomesso, DanielaDel Favero, SimoneCalore, RobertaCobelli, ClaudioAvogaro, AngeloFarret, AnnePlace, JeromeLy, Trang T.Shanmugham, SatyaPhillip, MosheDassau, EyalDasanayake, Isuru S.Kollman, CraigLum, John W.Beck, Roy W.Kovatchev, Boris2018-04-192016Anderson, S. M., D. Raghinaru, J. E. Pinsker, F. Boscari, E. Renard, B. A. Buckingham, R. Nimri, et al. 2016. “Multinational Home Use of Closed-Loop Control Is Safe and Effective.” Diabetes Care 39 (7): 1143-1150. doi:10.2337/dc15-2468. http://dx.doi.org/10.2337/dc15-2468.http://nrs.harvard.edu/urn-3:HUL.InstRepos:35982410OBJECTIVE To evaluate the efficacy of a portable, wearable, wireless artificial pancreas system (the Diabetes Assistant [DiAs] running the Unified Safety System) on glucose control at home in overnight-only and 24/7 closed-loop control (CLC) modes in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS At six clinical centers in four countries, 30 participants 18–66 years old with type 1 diabetes (43% female, 96% non-Hispanic white, median type 1 diabetes duration 19 years, median A1C 7.3%) completed the study. The protocol included a 2-week baseline sensor-augmented pump (SAP) period followed by 2 weeks of overnight-only CLC and 2 weeks of 24/7 CLC at home. Glucose control during CLC was compared with the baseline SAP. RESULTS Glycemic control parameters for overnight-only CLC were improved during the nighttime period compared with baseline for hypoglycemia (time <70 mg/dL, primary end point median 1.1% vs. 3.0%; P < 0.001), time in target (70–180 mg/dL: 75% vs. 61%; P < 0.001), and glucose variability (coefficient of variation: 30% vs. 36%; P < 0.001). Similar improvements for day/night combined were observed with 24/7 CLC compared with baseline: 1.7% vs. 4.1%, P < 0.001; 73% vs. 65%, P < 0.001; and 34% vs. 38%, P < 0.001, respectively. CONCLUSIONS CLC running on a smartphone (DiAs) in the home environment was safe and effective. Overnight-only CLC reduced hypoglycemia and increased time in range overnight and increased time in range during the day; 24/7 CLC reduced hypoglycemia and increased time in range both overnight and during the day. Compared with overnight-only CLC, 24/7 CLC provided additional hypoglycemia protection during the day.en-USJournal Article2018-04-1910.2337/dc15-2468