Faria-Urbina, MarianaOliveira, Rudolf K.F.Segrera, Sergio A.Lawler, LaurieWaxman, AaronSystrom, David2018-03-202018Faria-Urbina, Mariana, Rudolf K.F. Oliveira, Sergio A. Segrera, Laurie Lawler, Aaron B. Waxman, and David M. Systrom. 2018. “Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?” Pulmonary Circulation 8 (1): 2045893218755325. doi:10.1177/2045893218755325. http://dx.doi.org/10.1177/2045893218755325.http://nrs.harvard.edu/urn-3:HUL.InstRepos:35014939Ambrisentan in 22 patients with pulmonary hypertension diagnosed during exercise (ePH) improved pulmonary hemodynamics; however, there was only a trend toward increased maximum oxygen uptake (VO2max) secondary to decreased maximum exercise systemic oxygen extraction (Ca-vO2). We speculate that improved pulmonary hemodynamics at maximum exercise “unmasked” a pre-existing skeletal muscle abnormality.en-USsystemic oxygen extractionpulmonary hypertensionambrisentanexerciseJournal Article2018-03-2010.1177/2045893218755325