Shi, ConnieRobinson, SarahLaChance, AveryMihm Jr., Martin C.Kroshinsky, Daniela2018-03-202017Shi, Connie R., Sarah N. Robinson, Avery LaChance, Martin C. Mihm Jr., and Daniela Kroshinsky. 2017. “A 53-Year-Old Male with Relapsed Diffuse Large B-Cell Lymphoma on Chemotherapy with a New Leg Lesion.” Dermatopathology 4 (1-4): 31-35. doi:10.1159/000481307. http://dx.doi.org/10.1159/000481307.http://nrs.harvard.edu/urn-3:HUL.InstRepos:35014946Patients with underlying malignancy who develop new skin findings while acutely ill often require skin biopsy for histologic evaluation and/or culture to reach a diagnosis. Here, we present the case of a 53-year-old male with relapsed diffuse large B-cell lymphoma on chemotherapy who developed new skin lesions on the leg. On exam, there were 2 nickel-sized, erythematous to violaceous round plaques with central necrotic cores on the right lower leg with relatively nonspecific clinical features for which the initial differential diagnosis was broad. Consensus on a diagnosis was reached upon histologic evaluation of his skin biopsy in the context of his clinical setting. This diagnosis led to a change in treatment plan, with subsequent clinical improvement.en-USPhaeohyphomycosisJournal Article2018-03-2010.1159/000481307