Neppl, RonaldWu, Chia-LingWalsh, Kenneth2018-06-272017Neppl, Ronald L, Chia-Ling Wu, and Kenneth Walsh. 2017. “lncRNA Chronos is an aging-induced inhibitor of muscle hypertrophy.” The Journal of Cell Biology 216 (11): 3497-3507. doi:10.1083/jcb.201612100. http://dx.doi.org/10.1083/jcb.201612100.http://nrs.harvard.edu/urn-3:HUL.InstRepos:37160076Skeletal muscle exhibits remarkable plasticity in its ability to modulate its mass in response to the physiologic changes associated with functional use, systemic disease, and aging. Although a gradual loss of muscle mass normally occurs with advancing age, its increasingly rapid progression results in sarcopenia in a subset of individuals. The identities of muscle-enriched, long noncoding RNAs that regulate this process are unknown. Here, we identify a long noncoding RNA, named Chronos, whose expression in muscle is positively regulated with advancing age and negatively regulated during Akt1-mediated growth. Inhibition of Chronos induces myofiber hypertrophy both in vitro and in vivo, in part, through the epigenetic modulation of Bmp7 signaling.en-USReportJournal Article2018-06-2710.1083/jcb.201612100