Zaganjor, ElmaSpinelli, JessicaHaigis, Marcia2018-03-202017Zaganjor, Elma, Jessica B. Spinelli, and Marcia C. Haigis. 2017. “Strength in numbers: Phosphofructokinase polymerization prevails in the liver.” The Journal of Cell Biology 216 (8): 2239-2241. doi:10.1083/jcb.201706005. http://dx.doi.org/10.1083/jcb.201706005.http://nrs.harvard.edu/urn-3:HUL.InstRepos:35015040Numerous metabolic enzymes assemble into filamentous structures, which are thought to serve additional regulatory functions. In this issue, Webb et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701084) show that the liver-specific isoform of phosphofructokinase-1 forms filaments in vitro and localizes as puncta in cells along the plasma membrane. This suggests spatial organization of glycolysis in higher organisms.en-USSpotlightJournal Article2018-03-2010.1083/jcb.201706005