Demenais, FlorenceMargaritte-Jeannin, PatriciaBarnes, Kathleen CCookson, William OCAltmüller, JanineAng, WeiBarr, R GrahamBeaty, Terri HBecker, Allan BBeilby, JohnBisgaard, HansBjornsdottir, Unnur SteinaBleecker, EugeneBønnelykke, KlausBoomsma, Dorret IBouzigon, EmmanuelleBrightling, Christopher EBrossard, MyriamBrusselle, Guy GBurchard, EstebanBurkart, Kristin MBush, AndrewChan-Yeung, MoiraChung, Kian FanAlves, Alexessander CoutoCurtin, John ACustovic, AdnanDaley, Denisede Jongste, Johan CDel-Rio-Navarro, Blanca EDonohue, Kathleen MDuijts, LiesbethEng, CelesteEriksson, Johan GFarrall, MartinFedorova, YuliyaFeenstra, BjarkeFerreira, Manuel AFreidin, Maxim BGajdos, ZofiaGauderman, JimGehring, UlrikeGeller, FrankGenuneit, JonGharib, Sina AGilliland, FrankGranell, RaquelGraves, Penelope EGudbjartsson, Daniel FHaahtela, TariHeckbert, Susan RHeederik, DickHeinrich, JoachimHeliövaara, MarkkuHenderson, JohnHimes, Blanca EHirose, HiroshiHirschhorn, JoelHofman, AlbertHolt, PatrickHottenga, Jouke JanHudson, Thomas JHui, JennieImboden, MedeaIvanov, VladimirJaddoe, Vincent WVJames, AlanJanson, ChristerJarvelin, Marjo-RiittaJarvis, DeborahJones, GrahamJonsdottir, IngileifJousilahti, PekkaKabesch, MichaelKähönen, MikaKantor, DavidKarunas, Alexandra SKhusnutdinova, ElzaKoppelman, Gerard HKozyrskyj, Anita LKreiner, EskilKubo, MichiakiKumar, RajeshKumar, AshishKuokkanen, MikkoLahousse, LiesLaitinen, TarjaLaprise, CatherineLathrop, MarkLau, SusanneLee, Young-AeLehtimäki, TerhoLetort, SébastienLevin, Albert MLi, GuoLiang, LimingLoehr, Laura RLondon, Stephanie JLoth, Daan WManichaikul, AniMarenholz, IngoMartinez, Fernando JMatheson, Melanie CMathias, Rasika AMatsumoto, KenjiMbarek, HamdiMcArdle, Wendy LMelbye, MadsMelén, ErikMeyers, DeborahMichel, SvenMohamdi, HamidaMusk, Arthur WMyers, Rachel ANieuwenhuis, Maartje AENoguchi, EmikoO'Connor, George TOgorodova, Ludmila MPalmer, Cameron DPalotie, AarnoPark, Julie EPennell, Craig EPershagen, GöranPolonikov, AlexeyPostma, Dirkje SProbst-Hensch, NicolePuzyrev, Valery PRaby, BenjaminRaitakari, Olli TRamasamy, AdaikalavanRich, Stephen SRobertson, Colin FRomieu, IsabelleSalam, Muhammad TSalomaa, VeikkoSchlünssen, ViviScott, RobertSelivanova, Polina ASigsgaard, TorbenSimpson, AngelaSiroux, ValérieSmith, Lewis JSolodilova, MariaStandl, MarieStefansson, KariStrachan, David PStricker, Bruno HTakahashi, AtsushiThompson, Philip JThorleifsson, GudmarThorsteinsdottir, UnnurTiesler, Carla MTTorgerson, Dara GTsunoda, TatsuhikoUitterlinden, André Gvan der Valk, Ralf JPVaysse, AmauryVedantam, SailajaVon Berg, AndreaVon Mutius, ErikaVonk, Judith MWaage, JohannesWareham, Nick JWeiss, ScottWhite, Wendy BWickman, MagnusWidén, ElisabethWillemsen, GonnekeWilliams, L KeokiWouters, Inge MYang, James JZhao, Jing HuaMoffatt, Miriam FOber, CaroleNicolae, Dan L2018-07-252018Demenais, F., P. Margaritte-Jeannin, K. C. Barnes, W. O. Cookson, J. Altmüller, W. Ang, R. G. Barr, et al. 2018. “Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks.” Nature genetics 50 (1): 42-53. doi:10.1038/s41588-017-0014-7. http://dx.doi.org/10.1038/s41588-017-0014-7.http://nrs.harvard.edu/urn-3:HUL.InstRepos:37298460We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 cases, 118,538 controls) from ethnically-diverse populations. We identified five new asthma loci, uncovered two additional novel associations at two known asthma loci, established asthma associations at two loci implicated previously in comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. Enrichment of asthma risk loci in enhancer marks, especially in immune cells, suggests a major role of these loci in the regulation of immune-related mechanisms.en-USJournal Article2018-07-2510.1038/s41588-017-0014-7