Laing, GenevieveDupont, Pierre2017-09-122011Laing, Genevieve, and Pierre E. Dupont. 2011. "Beating-heart mitral valve chordal replacement." In Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE, pp. 2476-2479. doi:10.1109/IEMBS.2011.6090687http://nrs.harvard.edu/urn-3:HUL.InstRepos:33884749Replacing open-heart surgical procedures with beating-heart interventions substantially decreases the trauma and risk of a procedure. One of the most challenging procedures to perform on the beating heart is valve repair. To address this need, this paper proposes a tool for replacing mitral valve chordae to correct regurgitation. The chordae is secured to the papillary muscle and leaflet using NiTi tissue anchors that also incorporate an internal adjustment mechanism to enable initial adjustment as well as subsequent readjustment of chordae length. Efficacy of the proposed tool for chordae replacement and reduction of regurgitation was demonstrated in an ex-vivo heart simulator.en-USJournal Article2017-09-1210.1109/IEMBS.2011.6090687