Israel, ElliotDrazen, JeffreyO'Byrne, Paul2020-05-041999-01-21Jeffrey M. Drazen, Elliot Israel, and Paul M. O'Byrne. 1999. Treatment of Asthma with Drugs Modifying the Leukotriene Pathway. The New England Journal of Medicine 340, no. 23: 197-206.0028-47931533-4406http://nrs.harvard.edu/urn-3:HUL.InstRepos:42663146In 1979 and 1980, the chemical structures of the material previously known as slow-reacting substance of anaphylaxis were elucidated as 5(S)- hydroxy- 6(R)-glutathionyl- 7,9-trans-11,14- cis - eico- satetraenoic acid1 and its cysteinyl-glycyl and cysteinyl congener (also known as leukotrienes C4, D4, and E4, respectively). These molecules were so named because the parent molecule was originally isolated from leukocytes, and its carbon backbone contained three double bonds in series, which constitutes a triene. This structural information provided the key to the oxidative pathway of lipid metabolism known as the 5-lipoxygenase pathway.en-USGeneral MedicineJournal Article2017-12-0419992020-05-0410.1056/nejm199901213400306