Chen, Yan YunFan, Su JieLiang, Yuan BoRong, ShiMeng, Hai LinWang, XingThomas, RaviWang, Ning Li2017-12-062017Chen, Yan Yun, Su Jie Fan, Yuan Bo Liang, Shi Song Rong, Hai Lin Meng, Xing Wang, Ravi Thomas, and Ning Li Wang. 2017. “Laser Peripheral Iridotomy versus Trabeculectomy as an Initial Treatment for Primary Angle-Closure Glaucoma.” Journal of Ophthalmology 2017 (1): 2761301. doi:10.1155/2017/2761301. http://dx.doi.org/10.1155/2017/2761301.http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492316Purpose To compare laser peripheral iridotomy (LPI) with trabeculectomy as an initial treatment for primary angle-closure glaucoma (PACG) with peripheral anterior synechiae (PAS) ≥ 6 clock hours. Methods: Patients were drawn from two randomized controlled trials. 38 eyes of 38 patients (PAS ≥ 6 clock hours) were treated with LPI (group 1) while 111 eyes of 111 PACG patients (PAS ≥ 6 clock hours) underwent primary trabeculectomy (group 2). All patients underwent a comprehensive ophthalmic examination at baseline and at postoperative visits and were followed up for a minimum of one year. Results: Group 2 had higher baseline IOP (45.7 ± 14.8 mmHg versus 34.3 ± 14.3 mmHg) than group 1 and more clock hours of PAS (10.4 ± 1.9 versus 9.0 ± 2.2). IOPs at all postoperative visits were significantly lower in group 2 than in group 1 (p = 0.000). Five eyes in group 1 required trabeculectomy. 17 of the 38 eyes in group 1 (44.7%) required IOP-lowering medications as compared to seven of the 111 eyes in group 2 (6.3%). Cataract progression was documented in 2 eyes (5.3%) in group 1 and 16 eyes (14.4%) in group 2. Conclusions: Primary trabeculectomy for PACG (PAS ≥ 6 clock hours) is more effective than LPI in lowering IOP.en-USJournal Article2017-12-0610.1155/2017/2761301