Li, WendeYang, WeiningLiu, YujiaoChen, SiyuChin, ShanminQi, XiaolongZhao, YingchaoLiu, HaoWang, JiashengMei, XuetingHuang, PeigenXu, Donghui2017-12-062017Li, W., W. Yang, Y. Liu, S. Chen, S. Chin, X. Qi, Y. Zhao, et al. 2017. “MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma.” Oncotarget 8 (43): 73938-73946. doi:10.18632/oncotarget.17881. http://dx.doi.org/10.18632/oncotarget.17881.http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492344Glioblastoma multiforme is the most aggressive and common primary brain tumor, and is virtually incurable due to its therapeutic resistance to radiation and chemotherapy. Curcumin is a well-known phytochemical exhibiting antitumor activity on many human cancers including glioblastoma multiforme. Given the unique miRNA expression profiles in cancer cells compared to non-cancerous cells, we investigated whether these miRNA could be used to cancer therapy. In this report we show that miR-378, a glioblastoma multiforme down regulated miRNA, may enhance the inhibitory effect of curcumin on this cancer growth. Our results indicated that the inhibitory effect of curcumin was enhanced in miR-378-expressing stable U87 cells in vitro and in vivo, compared to control cells. MiR-378 was found to target p-p38 expression, underlying the observed phenotypic changes. Thus, we concluded that miR-378 enhances the response of glioblastoma multiforme to curcumin treatment, by targeting p38.en-USmiR-378glioblastomaU87curcuminJournal Article2017-12-0610.18632/oncotarget.17881