Andersen, Lena SMagidson, JessicaO’Cleirigh, ConallRemmert, Jessica EKagee, AshrafLeaver, MatthewStein, Dan JSafren, Steven AJoska, John2018-06-272016Andersen, Lena S, Jessica F Magidson, Conall O’Cleirigh, Jessica E Remmert, Ashraf Kagee, Matthew Leaver, Dan J Stein, Steven A Safren, and John Joska. 2016. “A pilot study of a nurse-delivered cognitive behavioral therapy intervention (Ziphamandla) for adherence and depression in HIV in South Africa.” Journal of Health Psychology 23 (6): 776-787. doi:10.1177/1359105316643375. http://dx.doi.org/10.1177/1359105316643375.http://nrs.harvard.edu/urn-3:HUL.InstRepos:37160259Depression is prevalent among people living with HIV in South Africa and interferes with adherence to antiretroviral therapy. This study evaluated a nurse-delivered, cognitive behavioral therapy intervention for adherence and depression among antiretroviral therapy users with depression in South Africa (n = 14). Primary outcomes were depression, antiretroviral therapy adherence, feasibility, and acceptability. Findings support robust improvements in mood through a 3-month follow up. Antiretroviral therapy adherence was maintained during the intervention period. Participant retention supports acceptability; however, modest provider fidelity despite intensive supervision warrants additional attention to feasibility. Future effectiveness research is needed to evaluate this nurse-delivered cognitive behavioral therapy intervention for adherence and depression in this context.en-USadherencecognitive behavioral therapydepressionHIVlow- and middle-income countriesSouth Africatask-sharingJournal Article2018-06-2710.1177/1359105316643375