Baudrand, ReneVaidya, Anand2018-04-192018Baudrand, Rene, and Anand Vaidya. 2018. “The Low-Renin Hypertension Phenotype: Genetics and the Role of the Mineralocorticoid Receptor.” International Journal of Molecular Sciences 19 (2): 546. doi:10.3390/ijms19020546. http://dx.doi.org/10.3390/ijms19020546.http://nrs.harvard.edu/urn-3:HUL.InstRepos:35982052A substantial proportion of patients with hypertension have a low or suppressed renin. This phenotype of low-renin hypertension (LRH) may be the manifestation of inherited genetic syndromes, acquired somatic mutations, or environmental exposures. Activation of the mineralocorticoid receptor is a common final mechanism for the development of LRH. Classically, the individual causes of LRH have been considered to be rare diseases; however, recent advances suggest that there are milder and “non-classical” variants of many LRH-inducing conditions. In this regard, our understanding of the underlying genetics and mechanisms accounting for LRH, and therefore, potentially the pathogenesis of a large subset of essential hypertension, is evolving. This review will discuss the potential causes of LRH, with a focus on implicated genetic mechanisms, the expanding recognition of non-classical variants of conditions that induce LRH, and the role of the mineralocorticoid receptor in determining this phenotype.en-USreninlow-reninhypertensionmineralocorticoid receptorgeneticsaldosteroneJournal Article2018-04-1910.3390/ijms19020546