Beltran, Brady E.Quiñones, PilarMorales, DomingoRevilla, Jose C.Alva, Jose C.Castillo, Jorge2021-08-312011-11-09Beltran, Brady E., Pilar Quiñones, Domingo Morales, Jose C. Revilla, Jose C. Alva, Jorge Castillo. "Diffuse Large B-Cell Lymphoma in Human T-Lymphotropic Virus Type 1 Carriers." Leukemia Research and Treatment 2012 (2011): 262363. DOI: 10.1155/2012/2623632090-32192090-3227https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369228We describe the clinical and pathological characteristics of seven patients who were human T-lymphotropic virus type 1 (HTLV-1) carriers and had a pathological diagnosis of de novo diffuse large B-cell lymphoma. Interestingly, three of our cases showed positive expression of Epstein-Barr-virus, (EBV-) encoded RNA within the tumor cells indicating a possible interaction between these two viruses. Furthermore, our three EBV-positive cases presented with similar clinical characteristics such as early clinical stage and low-risk indices. To the best of our knowledge, this is the first case series describing the characteristics of HTLV-1-positive DLBCL patients. The potential relationship between HTLV-1 and EBV should be further explored.en-USResearch Subject Categories::MEDICINE::Morphology, cell biology, pathology::Morphology::Tumour biologyResearch Subject Categories::MEDICINE::Dermatology and venerology,clinical genetics, internal medicine::Internal medicine::HaematologyJournal Article2017-08-1520122021-08-3110.1155/2012/262363