Fortier, CatherineDisterhoft, John F.Capozzi, StephenKilduff, PatrickCronin-Golomb, AliceMcGlinchey, Regina2021-10-142003-12Fortier, Catherine, John F. Disterhoft, Stephen Capozzi, Patrick Kilduff, Alice Cronin-Golomb, Regina McGlinchey. "Conditional Discrimination Learning in Patients with Bilateral Medial Temporal Lobe Amnesia." Behavioral Neuroscience 117, no. 6 (2003): 1181-1195. DOI: 10.1037/0735-7044.117.6.11811939-00840735-7044https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369766The ability of bilateral medial temporal lobe amnesic patients (MT; n = 8) and normal participants (NC; n = 8) to acquire a conditional discrimination in trace and delay eyeblink conditioning paradigms was investigated. Experiment 1 assessed trace conditional discrimination learning by using a light conditional stimulus (S+/S−) and tone conditioned stimulus (CS) separated by a 1-s trace. NCs responded differentially on S+ trials (mean percent conditioned responses = 66) versus S− trials (30), whereas MTs were impaired in their acquisition of the conditional discrimination (S+ = 51, S− = 43). In Experiment 2, the temporal separation was eliminated. NCs acquired the conditional discrimination (S+ = 70, S− = 29). MTs were unable to respond differentially (S+ = 42, S− = 37). The findings indicate that the hippocampal system is essential in acquiring a conditional discrimination, even in a delay paradigm.en-USJournal Article2017-08-1620032021-10-1410.1037/0735-7044.117.6.1181