Lee, J. J.Hwang, S.‐J.Mutalik, K.Corey, D.Joyce, R.Block, J. P.Fox, C. S.Powell‐Wiley, T. M.2017-12-062017Lee, J. J., S.‐J. Hwang, K. Mutalik, D. Corey, R. Joyce, J. P. Block, C. S. Fox, and T. M. Powell‐Wiley. 2017. “Association of built environment characteristics with adiposity and glycaemic measures.” Obesity Science & Practice 3 (3): 333-341. doi:10.1002/osp4.115. http://dx.doi.org/10.1002/osp4.115.http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492373Summary Objective: This study examined the cross‐sectional and longitudinal relationships of built environment characteristics with adiposity and glycaemic measures. Method Longitudinal study sample consisted of 4,010 Framingham Heart Study Offspring (baseline: 1998–2001; follow‐up: 2005–2008) and Generation Three (baseline: 2002–2005; follow‐up: 2008–2011) participants (54.8% women, baseline mean age 48.6 years). Built environment characteristics (intersection density, greenspace, recreation land and food stores) at baseline were collected. Adiposity and glycaemic measures (body mass index [BMI], waist circumference, abdominal subcutaneous and visceral adipose tissue, and fasting plasma glucose) at baseline and changes during 6.4‐year follow‐up were measured. Results: In cross‐sectional models, higher intersection density and food store density (total food stores, fast food restaurants and supermarkets) were linearly associated with higher BMI (all p < 0.05). Higher greenspace was associated with lower BMI, waist circumference, fasting plasma glucose, prevalent obesity and prevalent diabetes (all p < 0.05). Longitudinally, higher intersection density and food store density, and lower greenspace were associated with smaller increases in abdominal visceral adipose tissue (all p < 0.05). Higher densities of intersections, fast food restaurants and supermarkets were associated with smaller increases in fasting plasma glucose (all p < 0.05). Conclusions: Collectively, built environment characteristics are associated with adiposity and glycaemic traits, suggesting the potential mechanisms by which built environment influences cardiometabolic health.en-USOriginal ArticleDiabetesobesitysubcutaneous adipose tissuevisceral adipose tissueJournal Article2017-12-0610.1002/osp4.115