Cho, Chung-HyunWoo, Jin SeokPerez, ClaudioLee, Eun Hui2017-12-062017Cho, Chung-Hyun, Jin Seok Woo, Claudio F Perez, and Eun Hui Lee. 2017. “A focus on extracellular Ca2+ entry into skeletal muscle.” Experimental & Molecular Medicine 49 (9): e378. doi:10.1038/emm.2017.208. http://dx.doi.org/10.1038/emm.2017.208.http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492393The main task of skeletal muscle is contraction and relaxation for body movement and posture maintenance. During contraction and relaxation, Ca2+ in the cytosol has a critical role in activating and deactivating a series of contractile proteins. In skeletal muscle, the cytosolic Ca2+ level is mainly determined by Ca2+ movements between the cytosol and the sarcoplasmic reticulum. The importance of Ca2+ entry from extracellular spaces to the cytosol has gained significant attention over the past decade. Store-operated Ca2+ entry with a low amplitude and relatively slow kinetics is a main extracellular Ca2+ entryway into skeletal muscle. Herein, recent studies on extracellular Ca2+ entry into skeletal muscle are reviewed along with descriptions of the proteins that are related to extracellular Ca2+ entry and their influences on skeletal muscle function and disease.en-USJournal Article2017-12-0610.1038/emm.2017.208