Wang, YuanyuanZhou, HongZhang, LongZhong, QiuyueWang, QiaomeiShen, HaipingZhang, ManHuang, YanjieWang, AnqiNelson, KenradZhang, YipingYan, DonghaiPeng, ZuoqiZhang, YaXin, XiaonaZhang, HongguangZhao, JunWang, YanYang, YingHe, YuanXu, JihongLiu, XiaoliMa, Xu2017-12-062017Wang, Y., H. Zhou, L. Zhang, Q. Zhong, Q. Wang, H. Shen, M. Zhang, et al. 2017. “Prevalence of chronic hepatitis B and status of HBV care among rural women who planned to conceive in China.” Scientific Reports 7 (1): 12090. doi:10.1038/s41598-017-12005-2. http://dx.doi.org/10.1038/s41598-017-12005-2.http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492470Globally, one third of prevalent chronic hepatitis B (CHB) virus infection (HBV) occurred in China. Assessing the prevalence of CHB infesction and status of HBV-related services among pre-conception women will provide insight into risks of mother to child transmission (MTCT). A cross-sectional analysis of data from the National Free Pre-pregnancy Checkups (NFPC) program in 2010–2014 was conducted. A standardized questionnaire which collected demographic information and enzyme-linked immunosorbent assays (ELISA) which tested serological HBV markers were applied. A total of 16,051,850 rural women aged 15–49 years were included. 5.2% of women were infected with CHB, among whom, 28.6% were also hepatitis B e antigen (HBeAg) positive. The most CHB concentrated places were distributed in southeastern coastal provinces. Women born after 1992 did not experience a higher level of vaccine-induced immunity compared to those born before 1992. Nine in ten rural women with CHB were not aware of their HBV status and a very small proportion of women (0.22%) had received antiviral treatment. Our data demonstrated an overall high-intermediate burden of CHB. Heterogeneity of geographic distribution, high proportion of HBeAg, insufficient awareness of HBV status, and low access to HBV treatment are challenges for preventing the MTCT.en-USJournal Article2017-12-0610.1038/s41598-017-12005-2