Nellore, AnomaFishman, Jay2020-08-102015Nellore, Anoma, and Jay A. Fishman. 2015. “The Microbiome, Systemic Immune Function, and Allotransplantation.” Clinical Microbiology Reviews 29 (1) (December 9): 191–199. doi:10.1128/cmr.00063-15.0893-8512https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37364467Diverse effects of the microbiome on solid organ transplantation are beginning to be recognized. In allograft recipients, microbial networks are disrupted by immunosuppression, nosocomial and community-based infectious exposures, antimicrobial therapies, surgery, and immune processes. Shifting microbial patterns, in- cluding acute infectious exposures, have dynamic and reciprocal interactions with local and systemic immune systems. Both indi- vidual microbial species and microbial networks have central roles in the induction and control of innate and adaptive immune re- sponses, in graft rejection, and in ischemia-reperfusion injury. Understanding the diverse interactions between the microbiome and the immune system of allograft recipients may facilitate clin- ical management in the future.en-USJournal Article2017-12-0820162020-08-1010.1128/CMR.00063-15