Lam, AliceDeck, GinaGoldman, AlicaEskandar, EmadNoebels, JeffreyCole, Andrew2017-12-062017Lam, Alice D., Gina Deck, Alica Goldman, Emad N. Eskandar, Jeffrey Noebels, and Andrew J. Cole. 2017. “Silent Hippocampal Seizures and Spikes Identified by Foramen Ovale Electrodes in Alzheimer’s Disease.” Nature medicine 23 (6): 678-680. doi:10.1038/nm.4330. http://dx.doi.org/10.1038/nm.4330.http://nrs.harvard.edu/urn-3:HUL.InstRepos:34493070We directly assessed mesial temporal activity in two Alzheimer’s disease (AD) patients without a history or EEG evidence of seizures, using intracranial foramen ovale electrodes. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when both were most likely to interfere with memory consolidation. These index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD.en-USJournal Article2017-12-0610.1038/nm.4330