Freeman, Daniel K.O'Brien, Jonathan M.Kumar, ParshantDaniels, BrianIrion, Reed A.Shraytah, LouisIngersoll, Brett K.Magyar, Andrew P.Czarnecki, AndrewWheeler, JesseCoppeta, Jonathan R.Abban, Michael P.Gatzke, RonaldFried, ShelleyLee, Seung WooDuwel, Amy E.Bernstein, Jonathan J.Widge, AlikHernandez-Reynoso, AnaKanneganti, AswiniRomero-Ortega, Mario I.Cogan, Stuart F.2018-01-182017Freeman, D. K., J. M. O'Brien, P. Kumar, B. Daniels, R. A. Irion, L. Shraytah, B. K. Ingersoll, et al. 2017. “A Sub-millimeter, Inductively Powered Neural Stimulator.” Frontiers in Neuroscience 11 (1): 659. doi:10.3389/fnins.2017.00659. http://dx.doi.org/10.3389/fnins.2017.00659.http://nrs.harvard.edu/urn-3:HUL.InstRepos:34651861Wireless neural stimulators are being developed to address problems associated with traditional lead-based implants. However, designing wireless stimulators on the sub-millimeter scale (<1 mm3) is challenging. As device size shrinks, it becomes difficult to deliver sufficient wireless power to operate the device. Here, we present a sub-millimeter, inductively powered neural stimulator consisting only of a coil to receive power, a capacitor to tune the resonant frequency of the receiver, and a diode to rectify the radio-frequency signal to produce neural excitation. By replacing any complex receiver circuitry with a simple rectifier, we have reduced the required voltage levels that are needed to operate the device from 0.5 to 1 V (e.g., for CMOS) to ~0.25–0.5 V. This reduced voltage allows the use of smaller receive antennas for power, resulting in a device volume of 0.3–0.5 mm3. The device was encapsulated in epoxy, and successfully passed accelerated lifetime tests in 80°C saline for 2 weeks. We demonstrate a basic proof-of-concept using stimulation with tens of microamps of current delivered to the sciatic nerve in rat to produce a motor response.en-USwireless neural stimulationimplantable neurostimulatorselectroceuticalsinductive couplingmicrocoilJournal Article2018-01-1810.3389/fnins.2017.00659