van der Linden, CarlJakob, SusanneGupta, PoojaDulac, CatherineSantoro, Stephen W.2021-07-192018-12van der Linden, Carl, Susanne Jakob, Pooja Gupta, Catherine Dulac, Stephen W. Santoro. "Sex separation induces differences in the olfactory sensory receptor repertoires of male and female mice." Nat Commun 9, no. 1 (2018): 5081. DOI: 10.1038/s41467-018-07120-12041-1723https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368617Within the mammalian olfactory sensory epithelium, experience-dependent changes in the rate of neuronal turnover can alter the relative abundance of neurons expressing specific chemoreceptors. Here we investigate how the mouse olfactory sensory receptor repertoire changes as a function of exposure to odors emitted from members of the opposite sex, which are highly complex and sexually dimorphic. Upon housing mice either sex-separated or sex-combined until six months of age, we find that sex-separated mice exhibit significantly more numerous differentially expressed genes within their olfactory epithelia. A subset of these chemoreceptors exhibit altered expression frequencies following both sex-separation and olfactory deprivation. We show that several of these receptors detect either male- or female-specific odors. We conclude that the distinct odor experiences of sex-separated male and female mice induce sex-specific differences in the abundance of neurons that detect sexually dimorphic odors.en-USGeneral Physics and AstronomyGeneral Biochemistry, Genetics and Molecular BiologyGeneral ChemistryJournal Article2021-07-1910.1038/s41467-018-07120-1