Ikeda, A.Iso, H.Kawachi, I.Yamagishi, K.Inoue, M.Tsugane, S.2019-08-292008Ikeda, A, H Iso, I Kawachi, K Yamagishi, M Inoue, and S Tsugane. 2008. “Living Arrangement and Coronary Heart Disease: The JPHC Study.” Heart 95 (7): 577–83. https://doi.org/10.1136/hrt.2008.149575.1355-60371468-201Xhttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41275557Background: Previous studies have suggested that living in a multi-generational household (a type of family structure prevalent in Japan) confers mixed health benefits and stresses, especially for women who report such living arrangements. Objective: To examine, in a prospective cohort study, the impact of living arrangements on the incidence of coronary heart disease (CHD) and mortality as well as all-cause mortality in a large prospective cohort of the Japanese population. Methods: The association between living arrangements and risk of CHD and mortality was examined prospectively within a cohort of 90 987 Japanese women and men aged 40-69 years, free of prior diagnosis of cancer and cardiovascular disease. A total of 671 cases of newly diagnosed CHD, 339 CHD deaths and 6255 all-cause deaths occurred between the baseline questionnaire (1990-4) and the end of follow-up in January 2004. Results: After adjustment for potentially confounding variables, women living in multi-generational households (ie, with spouse-children-parents;or spouse-parents) had a two-to threefold higher risk of CHD than women living with spouses only. Women living with spouses and children also had a 2.1-fold higher risk of CHD incidence compared with married women living without children. Conclusions: Women in a multi-generational family had a higher risk of CHD, probably due to stress from multiple family roles.en-USJournal Article2019-08-2910.1136/hrt.2008.149575