Wang, MolinLiao, XiaomeiLaden, FrancineSpiegelman, Donna2019-09-212016Wang, Molin, Xiaomei Liao, Francine Laden, and Donna Spiegelman. 2016. “Quantifying Risk over the Life Course - Latency, Age-Related Susceptibility, and Other Time-Varying Exposure Metrics.” Statistics in Medicine 35 (13): 2283–95. https://doi.org/10.1002/sim.6864.0277-67151097-0258http://nrs.harvard.edu/urn-3:HUL.InstRepos:41384776Identification of the latency period and age-related susceptibility, if any, is an important aspect of assessing risks of environmental, nutritional, and occupational exposures. We consider estimation and inference for latency and age-related susceptibility in relative risk and excess risk models. We focus on likelihood-based methods for point and interval estimation of the latency period and age-related windows of susceptibility coupled with several commonly considered exposure metrics. The method is illustrated in a study of the timing of the effects of constituents of air pollution on mortality in the Nurses' Health Study.en-USJournal Article2019-09-2110.1002/sim.6864