Kim, Dong-HyunSmith-Warner, Stephanie A.Spiegelman, DonnaYaun, Shiaw-ShyuanColditz, Graham A.Freudenheim, Jo L.Giovannucci, EdwardGoldbohm, R. AlexandraGraham, SaxonHarnack, LisaJacobs, Eric J.Leitzmann, MichaelMannisto, SatuMiller, Anthony B.Potter, John D.Rohan, Thomas E.Schatzkin, ArthurSpeizer, Frank E.Stevens, Victoria L.Stolzenberg-Solomon, RachaelTerry, PaulToniolo, PaoloWeijenberg, Matty P.Willett, WalterWolk, AlicjaZeleniuch-Jacquotte, AnneHunter, David J.2019-09-212010Kim, Dong-Hyun, Stephanie A. Smith-Warner, Donna Spiegelman, Shiaw-Shyuan Yaun, Graham A. Colditz, Jo L. Freudenheim, Edward Giovannucci, et al. 2010. “Pooled Analyses of 13 Prospective Cohort Studies on Folate Intake and Colon Cancer.” Cancer Causes & Control 21 (11): 1919–30. https://doi.org/10.1007/s10552-010-9620-8.0957-52431573-7225http://nrs.harvard.edu/urn-3:HUL.InstRepos:41384774Studies of folate intake and colorectal cancer risk have been inconsistent. We examined the relation with colon cancer risk in a series of 13 prospective studies.Study- and sex-specific relative risks (RRs) were estimated from the primary data using Cox proportional hazards models and then pooled using a random-effects model.Among 725,134 participants, 5,720 incident colon cancers were diagnosed during follow-up. The pooled multivariate RRs (95% confidence interval [CI]) comparing the highest vs. lowest quintile of intake were 0.92 (95% CI 0.84-1.00, p-value, test for between-studies heterogeneity = 0.85) for dietary folate and 0.85 (95% CI 0.77-0.95, p-value, test for between-studies heterogeneity = 0.42) for total folate. Results for total folate intake were similar in analyses using absolute intake cutpoints (pooled multivariate RR = 0.87, 95% CI 0.78-0.98, comparing a parts per thousand yen560 mcg/days vs. < 240 mcg/days, p-value, test for trend = 0.009). When analyzed as a continuous variable, a 2% risk reduction (95% CI 0-3%) was estimated for every 100 mu g/day increase in total folate intake.These data support the hypothesis that higher folate intake is modestly associated with reduced risk of colon cancer.en-USJournal Article2019-09-2110.1007/s10552-010-9620-8