Li, YingweiStec, GrantKim, HongkiThapa, SurendraMcClelland, ArthurZheng, Shao-LiangMason, Jaradmccllelland, arthur2025-02-112025-01-08Li, Yingwei, Grant Stec, Hongki Kim, Surendra Thapa, Arthur McClelland, Shao-Liang Zheng, Jarad Mason et al. "Self-assembly of chiroptical ionic co-crystals from silver nanoclusters and organic macrocycles." Nat. Chem. 17, no. 2 (2025): 169-176. DOI: 10.1038/s41557-024-01696-61755-43301755-4349https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37380358Atomically precise nanoclusters can be assembled into ordered superlattices with unique electronic, magnetic, optical, and catalytic properties. The co-crystallization of nanoclusters with functional organic molecules provides opportunities to access an even wider range of structures and properties but can be challenging to control synthetically. Here, we introduce a supramolecular approach to direct the assembly of atomically precise Ag nanoclusters into a series of nanocluster‒organic ionic cocrystals (NOICs) with tunable structures and properties. By leveraging non-covalent interactions between anionic Ag nanoclusters and cationic organic macrocycles with tunable sizes, the orientation of nanocluster surface ligands can be manipulated to achieve in-situ resolution of enantiopure NOICs that feature large chiroptical effects. Beyond chirality, this cocrystal assembly approach provides a promising platform for designing functional solid-state nanomaterials through a combination of supramolecular chemistry and atomically precise nanochemistry.en-USJournal Article2025-02-1110.1038/s41557-024-01696-6