Zeidler, Martin P.Perrimon, NorbertStrutt, David I.2021-07-301999-05-15Zeidler, Martin P., Norbert Perrimon, David I. Strutt. "Polarity Determination in the Drosophila Eye: A Novel Role for Unpaired and JAK/STAT Signaling." Genes & Development 13, no. 10 (1999): 1342-1353. DOI: 10.1101/gad.13.10.13420890-93691549-5477https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368809The JAK/STAT signaling pathway is required for many processes including cytokine signaling, hematopoiesis, gliagenesis, and Drosophila segmentation. In this report we present evidence demonstrating that the JAK/STAT pathway is also central to the establishment of planar polarity during Drosophila eye development. We show that a localized source of the pathway ligand, Unpaired, is present at the midline of the developing eye, which is capable of activating the JAK/STAT pathway over long distances. A gradient of JAK/STAT activity across the DV axis of the eye regulates ommatidial polarity via an unidentified second signal. Additionally, localized Unpaired influences the position of the equator via repression of mirror.en-USResearch Subject Categories::NATURAL SCIENCES::Biology::Organism biology::Developmental biologyJournal Article2021-07-3010.1101/gad.13.10.1342