Gepner, YftachHenkin, YaakovSchwarzfuchs, DanGolan, RachelDurst, RonenShelef, IlanHarman-Boehm, IlanaSpitzen, ShosanaWitkow, ShulaNovack, LenaFriger, MichaelTangi-Rosental, OsnatSefarty, DanaBril, NitzanRein, MichalCohen, NoaChassidim, YoashSarusi, BennyWolak, TaliaStampfer, MeirRudich, AssafShai, Iris2019-09-052016Gepner, Yftach, Yaakov Henkin, Dan Schwarzfuchs, Rachel Golan, Ronen Durst, Ilan Shelef, Ilana Harman-Boehm, et al. 2015. “Differential Effect of Initiating Moderate Red Wine Consumption on 24-H Blood Pressure by Alcohol Dehydrogenase Genotypes: Randomized Trial in Type 2 Diabetes.” American Journal of Hypertension 29 (4): 476–83. https://doi.org/10.1093/ajh/hpv126.0895-70611879-19051941-7225http://nrs.harvard.edu/urn-3:HUL.InstRepos:41292483AIMS Observational studies report inconsistent associations between moderate alcohol intake and blood pressure (BP). In a sub-study of a larger randomized controlled trial, we assessed the effect of initiating moderate red wine consumption on 24-h BP recordings and the effect of a common genetic variant of alcohol dehydrogenases (ADH) among patients with type 2 diabetes. METHODS Fifty-four type 2 diabetes, alcohol abstainers were randomized to consume 150ml/dinner dry red wine or mineral water. Both groups were guided to adhere to a Mediterranean diet, without caloric restriction. We measured 24-h ambulatory BP monitoring (ABPM) at baseline and after 6 months. RESULTS Participants (age = 57 years; 85% men; mean 24-h BP = 129/77mm Hg) had 92% 6-month retention. After 6 months of intervention, the average 24-h BP did not differ between the wine and water groups. A transient decrease in BP was observed in the red wine group at midnight (3-4 hours after wine intake: systolic BP: red wine = -10.6mm Hg vs. mineral water = +2.3mm Hg; P = 0.031) and the following morning at 7-9 am (red wine: -6.2mm Hg vs. mineral water: +5.6mm Hg; P = 0.014). In a second post hoc sub-analysis among the red wine consumers, individuals who were homozygous for the gene encoding ADH1B*2 variant (Arg48His; rs1229984, TT, fast ethanol metabolizers), exhibited a reduction in mean 24-h systolic BP (-8.0mm Hg vs. +3.7mm Hg; P = 0.002) and pulse pressure (-3.8mm Hg vs. +1.2mm Hg; P = 0.032) compared to heterozygotes and those homozygous for the ADH1B*1 variant (CC, slow metabolizers). CONCLUSIONS Initiating moderate red wine consumption at dinner among type 2 diabetes patients does not have a discernable effect on mean 24-h BP. Yet, a modest temporal BP reduction could be documented, and a more pronounced BP-lowering effect is suggested among fast ethanol metabolizers.en-USJournal Article2019-09-0510.1093/ajh/hpv126