Fan, Xiang-ShanChen, Jie-YuLi, Chang-FengZhang, Yi-FenMeng, Fan-QingWu, Hong-YanFeng, An-NingHuang, Qin2019-10-132013Fan, Xiang-Shan. 2013. “Differences in HER2 Over-Expression between Proximal and Distal Gastric Cancers in the Chinese Population.” World Journal of Gastroenterology 19 (21): 3316. doi:10.3748/wjg.v19.i21.3316.1007-93272219-2840http://nrs.harvard.edu/urn-3:HUL.InstRepos:41542746AIM: To investigate HER2 expression and its correlation with clinicopathological variables between proximal and distal gastric cancers (GC) in the Chinese population.METHODS: Immunostaining of HER2 was performed and scored on a scale of 0-3 in 957 consecutive GC cases, according to the revised scoring criteria of HercepTest (TM) as used in the ToGA trial. Correlations between HER2 expression and clinicopathologic variables of proximal (n = 513) and distal (n = 444) GC were investigated. RESULTS : Our results showed that HER2 expression was significantly higher in the proximal than in distal GC (P < 0.05). Overall, HER2 expression was significantly higher in male patients (P < 0.01), the Lauren intestinal type (P < 0.001), low-grade (P < 0.001) and pM1 (P < 0.01) diseases, respectively. There was a significant difference in HER2 expression among some pTNM stages (P < 0.05). In contrast, HER2 expression in the distal GC was significantly higher in male patients (P < 0.001), low-grade histology (P < 0.001), the Lauren intestinal type(P < 0.001), and pM1 (P < 0.001). In the proximal GC, however, higher HER2 expression scores were observed only in tumors with low-grade histology (P < 0.001) and the Lauren intestinal type (P < 0.001). CONCLUSION : HER2 over-expression in GC of Chinese patients was significantly more common in proximal than in distal GC, and significantly correlated with the Lauren intestinal type and low-grade histology in both proximal and distal GC, and with pM1 disease and male gender in distal GC.en-USJournal Article2019-10-1310.3748/wjg.v19.i21.3316