Grøntved, AndersRimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600Willett, WalterAndersen, Lars B.Hu, Frank B.2019-08-262012Grøntved, Anders, Eric B. Rimm, Walter C. Willett, Lars B. Andersen, and Frank B. Hu. 2012. “A Prospective Study of Weight Training and Risk of Type 2 Diabetes Mellitus in Men.” Archives of Internal Medicine 172 (17): 1306. https://doi.org/10.1001/archinternmed.2012.3138.0003-99261538-3679http://nrs.harvard.edu/urn-3:HUL.InstRepos:41247272Background: The role of weight training in the primary prevention of type 2 diabetes mellitus (T2DM) is largely unknown. Methods: To examine the association of weight training with risk of T2DM in US men and to assess the influence of combining weight training and aerobic exercise, we performed a prospective cohort study of 32 002 men from the Health Professionals Follow-up Study observed from 1990 to 2008. Weekly time spent on weight training and aerobic exercise (including brisk walking, jogging, running, bicycling, swimming, tennis, squash, and calisthenics/rowing) was obtained from questionnaires at baseline and biennially during follow-up. Results: During 508 332 person-years of follow-up (18 years), we documented 2278 new cases of T2DM. In multivariable-adjusted models, we observed a dose-response relationship between an increasing amount of time spent on weight training or aerobic exercise and lower risk of T2DM (P < .001 for trend). Engaging in weight training or aerobic exercise for at least 150 minutes per week was independently associated with a lower risk of T2DM of 34% (95% CI, 7%-54%) and 52% (95% CI, 45%-58%), respectively. Men who engaged in aerobic exercise and weight training for at least 150 minutes per week had the greatest reduction in T2DM risk (59%; 95% CI, 39%-73%). Conclusions: Weight training was associated with a significantly lower risk of T2DM, independent of aerobic exercise. Combined weight training and aerobic exercise conferred a greater benefit.en-USJournal Article2019-08-2610.1001/archinternmed.2012.3138