Rosner, SarahÅkesson, AgnetaStampfer, MeirWolk, Alicja2019-09-062007Rosner, S. A., A. Akesson, M. J. Stampfer, and A. Wolk. 2006. “Coffee Consumption and Risk of Myocardial Infarction among Older Swedish Women.” American Journal of Epidemiology 165 (3): 288–93. https://doi.org/10.1093/aje/kwk013.0002-92621476-6256http://nrs.harvard.edu/urn-3:HUL.InstRepos:41292859Numerous studies have examined the association between coffee consumption and risk of myocardial infarction (MI), but results have been inconsistent. Case-control studies generally suggest a harmful effect of coffee drinking, whereas cohort studies have mostly shown no association. Recent studies found that coffee may lower the risk of diabetes, a major coronary risk factor. The authors prospectively examined the effect of coffee consumption on MI risk in 32,650 older Swedish women, aged 40-74 years, participating in the Swedish Mammography Cohort; 459 cases of MI developed during 165,896 person-years of follow-up from 1997 to 2002. After adjustment for age, coronary heart disease risk factors, and dietary variables, the relative risk of MI associated with drinking >= 5 cups/week versus 0-4 cups/week was 0.68 (95% confidence interval (CI): 0.43, 1.07). The authors observed a nonsignificant trend toward lower risk with higher consumption levels. Compared with that for 0-4 cups/week, the relative risks of MI were 0.84 ( 95% CI: 0.51, 1.38) for 5-7 cups/week, 0.65 ( 95% CI: 0.41, 1.03) for 2-3 cups/day, 0.64 ( 95% CI: 0.39, 1.04) for 4-5 cups/day, and 0.65 ( 95% CI: 0.37, 1.12) for >= 6 cups/day (p-trend = 0.07). Contrary to previous case-control studies, the authors concluded that coffee consumption does not increase MI risk. Coffee consumption of >= 5 cups/week was nonsignificantly inversely associated with MI risk among older Swedish women.en-USJournal Article2019-09-0610.1093/aje/kwk013