Song, WeiOwusu-Ansah, EdwardHu, YanhuiCheng, DaojunNi, XiaochunZirin, JonathanPerrimon, Norbert2021-06-242017-08-08Song, Wei, Edward Owusu-Ansah, Yanhui Hu, Daojun Cheng, Xiaochun Ni, Jonathan Zirin, Norbert Perrimon. "Activin Signaling Mediates Muscle-to-Adipose Communication in a Mitochondria Dysfunction-Associated Obesity Model." Proceedings of the National Academy of Sciences 114, no. 32 (2017): 8596-8601. DOI: 10.1073/pnas.17080371140027-84241091-6490https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368034Mitochondrial perturbation-associated dysregulation of one organ has been shown to nonautonomously affect the functions of other organs in both vertebrates and invertebrates. Using Drosophila as a genetic model organism, we characterized mitochondrial synchrony dysregulation across organs and uncovered that mitochondrial perturbation caused by complex I disruption in muscles remotely impairs mitochondrial function and lipid mobilization in the fat body, leading to obesity. We further identified that the TGF-β ligand Actβ, which is autonomously increased by muscular mitochondrial perturbation, mediates muscle-to-fat-body communication and synchronized mitochondrial dysregulation.en-USResearch Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistry::Functional genomicsJournal Article2021-06-2410.1073/pnas.1708037114