Krishnan, LavanyaEngelman, Alan2019-10-052012Krishnan, Lavanya, and Alan Engelman. 2012. “Retroviral Integrase Proteins and HIV-1 DNA Integration.” Journal of Biological Chemistry 287 (49): 40858–66. https://doi.org/10.1074/jbc.r112.397760.0021-92581083-351Xhttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41483052Retroviral integrases catalyze two reactions, 3'-processing of viral DNA ends, followed by integration of the processed ends into chromosomal DNA. X-ray crystal structures of integrase-DNA complexes from prototype foamy virus, a member of the Spumavirus genus of Retroviridae, have revealed the structural basis of integration and how clinically relevant integrase strand transfer inhibitors work. Underscoring the translational potential of targeting virus-host interactions, small molecules that bind at the host factor lens epithelium-derived growth factor/p75-binding site on HIV-1 integrase promote dimerization and inhibit integrase-viral DNA assembly and catalysis. Here, we review recent advances in our knowledge of HIV-1 DNA integration, as well as future research directions.en-USJournal Article2019-10-0510.1074/jbc.R112.397760