Jaffer, Farouc A.Libby, PeterWeissleder, Ralph2019-09-212009Jaffer, Farouc A., Peter Libby, and Ralph Weissleder. 2009. “Optical and Multimodality Molecular Imaging.” Arteriosclerosis, Thrombosis, and Vascular Biology 29 (7): 1017–24. https://doi.org/10.1161/atvbaha.108.165530.1079-56421524-4636http://nrs.harvard.edu/urn-3:HUL.InstRepos:41384382Imaging approaches that visualize molecular targets rather than anatomic structures aim to illuminate vital molecular and cellular aspects of atherosclerosis biology in vivo. Several such molecular imaging strategies stand ready for rapid clinical application. This review describes the growing role of in vivo optical molecular imaging in atherosclerosis and highlights its ability to visualize atheroma inflammation, calcification, and angiogenesis. In addition, we discuss advances in multimodality probes, both in the context of multimodal imaging as well as multifunctional, or "theranostic," nanoparticles. This review highlights particular molecular imaging strategies that possess strong potential for clinical translation. (Arterioscler Thromb Vasc Biol. 2009; 29: 1017-1024.)en-USJournal Article2019-09-2110.1161/ATVBAHA.108.165530