Satizabal, Claudia L.Adams, Hieab H. H.Hibar, Derrek P.White, Charles C.Knol, Maria J.Stein, Jason L.Scholz, MarkusSargurupremraj, MuralidharanJahanshad, NedaRoshchupkin, Gennady V.Smith, Albert V.Bis, Joshua C.Jian, XueqiuLuciano, MichelleHofer, EdithTeumer, Alexandervan der Lee, Sven J.Yang, JingyunYanek, Lisa R.Lee, Tom V.Li, ShuoHu, YanhuiKoh, Jia YuEicher, John D.Desrivières, SylvaneArias-Vasquez, AlejandroChauhan, GaneshAthanasiu, LaviniaRentería, Miguel E.Kim, SungeunHoehn, DavidArmstrong, Nicola J.Chen, QiangHolmes, Avram J.den Braber, AnoukKloszewska, IwonaAndersson, MicaelEspeseth, ThomasGrimm, OliverAbramovic, LucijaAlhusaini, SaudMilaneschi, YuriPapmeyer, MartinaAxelsson, TomasEhrlich, StefanRoiz-Santiañez, RobertoKraemer, BerndHåberg, Asta K.Jones, Hannah J.Pike, G. BruceStein, Dan J.Stevens, AllisonBralten, JanitaVernooij, Meike W.Harris, Tamara B.Filippi, IrinaWitte, A. VeronicaGuadalupe, TulioWittfeld, KatharinaMosley, Thomas H.Becker, James T.Doan, Nhat TrungHagenaars, Saskia P.Saba, YasamanCuellar-Partida, GabrielAmin, NajafHilal, SaimaNho, KwangsikMirza-Schreiber, NazaninArfanakis, KonstantinosBecker, Diane M.Ames, DavidGoldman, Aaron L.Boomsma, Dorret I.Lovestone, SimonGiddaluru, SudheerLe Hellard, StephanieMattheisen, ManuelBohlken, Marc M.Kasperaviciute, DaliaSchmaal, LianneLawrie, Stephen M.Agartz, IngridWalton, EstherTordesillas-Gutierrez, DianaDavies, Gareth E.Shin, JeanIpser, Jonathan C.Vinke, Louis N.Hoogman, MartineJia, TianyeBurkhardt, RalphKlein, MariekeCrivello, FabriceJanowitz, DeborahCarmichael, OwenHaukvik, Unn K.Aribisala, Benjamin S.Schmidt, HelenaStrike, Lachlan T.Cheng, Ching-YuRisacher, Shannon L.Pütz, BennoFleischman, Debra A.Assareh, Amelia A.Mattay, Venkata S.Mecocci, PatriziaDale, Anders M.Cichon, SvenBoks, Marco P.Matarin, MarPenninx, Brenda W. J. H.Calhoun, Vince D.Chakravarty, M. MallarMarquand, Andre F.Macare, ChristineKharabian Masouleh, ShahrzadOosterlaan, JaapAmouyel, PhilippeHegenscheid, KatrinRotter, Jerome I.Schork, Andrew J.Liewald, David C. M.de Zubicaray, Greig I.Wong, Tien YinShen, LiSämann, Philipp G.Brodaty, HenryRoffman, Joshua L.de Geus, Eco J. C.Tsolaki, MagdaErk, Susannevan Eijk, Kristel R.Cavalleri, Gianpiero L.van der Wee, Nic J. A.McIntosh, Andrew M.Gollub, RandyBulayeva, Kazima B.Bernard, ManonRichards, Jennifer S.Himali, Jayandra J.Loeffler, MarkusRommelse, NandaHoffmann, WolfgangWestlye, Lars T.Valdés Hernández, Maria C.Hansell, Narelle K.van Erp, Theo G. M.Wolf, ChristianeKwok, John B. J.Vellas, BrunoHeinz, AndreasOlde Loohuis, Loes M.Delanty, NormanHo, Beng-ChoonChing, Christopher R. K.Shumskaya, ElenaSingh, BaljeetHofman, Albertvan der Meer, DennisHomuth, GeorgPsaty, Bruce M.Bastin, Mark E.Montgomery, Grant W.Foroud, Tatiana M.Reppermund, SimoneHottenga, Jouke-JanSimmons, AndrewMeyer-Lindenberg, AndreasCahn, WiepkeWhelan, Christopher D.van Donkelaar, Marjolein M. J.Yang, QiongHosten, NorbertGreen, RobertThalamuthu, AnbupalamMohnke, SebastianHulshoff Pol, Hilleke E.Lin, HonghuangJack, Clifford R.Schofield, Peter R.Mühleisen, Thomas W.Maillard, PaulinePotkin, Steven G.Wen, WeiFletcher, EvanToga, Arthur W.Gruber, OliverHuentelman, MatthewDavey Smith, GeorgeLauner, Lenore J.Nyberg, LarsJönsson, Erik G.Crespo-Facorro, BenedictoKoen, NastassjaGreve, DouglasUitterlinden, André G.Weinberger, Daniel R.Steen, Vidar M.Fedko, Iryna O.Groenewold, Nynke A.Niessen, Wiro J.Toro, RobertoTzourio, ChristopheLongstreth, William T.Ikram, M. Kamranvan Tol, Marie-JoseSussmann, Jessika E.Paus, TomasLemaître, HervéSchroeter, Matthias L.Mazoyer, BernardAndreassen, Ole A.Holsboer, FlorianDepondt, ChantalVeltman, Dick J.Turner, Jessica A.Pausova, ZdenkaSchumann, Guntervan Rooij, DaanDjurovic, SrdjanDeary, Ian J.McMahon, Katie L.Müller-Myhsok, BertramBrouwer, Rachel M.Soininen, HilkkaPandolfo, MassimoWassink, Thomas H.Cheung, Joshua W.Wolfers, ThomasMartinot, Jean-LucZwiers, Marcel P.Nauck, MatthiasMelle, IngridMartin, Nicholas G.Kanai, RyotaWestman, EricKahn, René S.Sisodiya, Sanjay M.White, TonyaSaremi, Arvinvan Bokhoven, HansBrunner, Han G.Völzke, HenryWright, Margaret J.van ‘t Ent, DennisNöthen, Markus M.Ophoff, Roel A.Buitelaar, Jan K.Fernández, GuillénSachdev, Perminder S.Rietschel, Marcellavan Haren, Neeltje E. M.Fisher, Simon E.Beiser, Alexa S.Francks, ClydeSaykin, Andrew J.Mather, Karen A.Romanczuk-Seiferth, NinaHartman, Catharina A.DeStefano, Anita L.Heslenfeld, Dirk J.Weiner, Michael W.Walter, HenrikHoekstra, Pieter J.Nyquist, Paul A.Franke, BarbaraBennett, David A.Grabe, Hans J.Johnson, Andrew D.Chen, Christophervan Duijn, Cornelia M.Lopez, Oscar L.Fornage, MyriamWardlaw, Joanna M.Schmidt, ReinholdDeCarli, CharlesDe Jager, Philip L.Villringer, ArnoDebette, StéphanieGudnason, VilmundurMedland, Sarah E.Shulman, Joshua M.Thompson, Paul M.Seshadri, SudhaIkram, M. ArfanLee, PhilipSmoller, JordanBuckner, Randy2023-03-272019-10-21Satizabal, Claudia L., Hieab H. H. Adams, Derrek P. Hibar, Charles C. White, Maria J. Knol, Jason L. Stein, Markus Scholz, Muralidharan Sargurupremraj, et al. 2019. Genetic Architecture of Subcortical Brain Structures in 38,851 Individuals. Nature Genetics 51, no. 11: 1624-636.1061-40361546-1718https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37374692Subcortical brain structures are integral to motion, consciousness, emotions, and learning. We identified common genetic variation related to the volumes of nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen, and thalamus, using genome-wide association analyses in over 40,000 individuals from CHARGE, ENIGMA and the UK-Biobank. We show that variability in subcortical volumes is heritable, and identify 25 significantly associated loci (20 novel). Annotation of these loci utilizing gene expression, methylation, and neuropathological data identified 62 candidate genes implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.en-USGeneticsJournal Article2023-03-2710.1038/s41588-019-0511-y