Lawson, ChristinaRocheleau, CarissaWhelan, ElizabethHibert, Eileen N. LividotiGrajewski, BarbaraSpiegelman, DonnaRich-Edwards, Janet2019-09-212012Lawson, Christina C., Carissa M. Rocheleau, Elizabeth A. Whelan, Eileen N. Lividoti Hibert, Barbara Grajewski, Donna Spiegelman, and Janet W. Rich-Edwards. 2012. “Occupational Exposures among Nurses and Risk of Spontaneous Abortion.” American Journal of Obstetrics and Gynecology 206 (4): 327.e1-327.e8. https://doi.org/10.1016/j.ajog.2011.12.030.0002-93781085-87091097-6868http://nrs.harvard.edu/urn-3:HUL.InstRepos:41384678OBJECTIVE: We investigated self-reported occupational exposure to antineoplastic drugs, anesthetic gases, antiviral drugs, sterilizing agents (disinfectants), and X-rays and the risk of spontaneous abortion in US nurses.STUDY DESIGN: Pregnancy outcome and occupational exposures were collected retrospectively from 8461 participants of the Nurses' Health Study II. Of these, 7482 were eligible for analysis using logistic regression. RESULTS : Participants reported 6707 live births, and 775 (10%) spontaneous abortions (<20 weeks). After adjusting for age, parity, shift work, and hours worked, antineoplastic drug exposure was associated with a 2-fold increased risk of spontaneous abortion, particularly with early spontaneous abortion before the 12th week, and 3.5-fold increased risk among nulliparous women. Exposure to sterilizing agents was associated with a 2-fold increased risk of late spontaneous abortion (12-20 weeks), but not with early spontaneous abortion. CONCLUSION : This study suggests that certain occupational exposures common to nurses are related to risks of spontaneous abortion.en-USJournal Article2019-09-2110.1016/j.ajog.2011.12.030