Browsing by Author "Parikh, Samir"

Now showing items 1-7 of 7

    • Angiopoietin-1 Requires Oxidant Signaling through p47phox to Promote Endothelial Barrier Defense 

      Ghosh, Chandra C.; Mukherjee, Aditi; David, Sascha; Milam, Katelyn E.; Hunter, Jon T.; Parikh, Samir M. (Public Library of Science, 2015)
      Background: Reactive oxygen species (ROS) are largely considered to be pathogenic to normal endothelial function in disease states such as sepsis. We hypothesized that Angiopoietin-1 (Angpt-1), an endogenous agonist of the ...

    • A branched chain amino acid metabolite drives vascular transport of fat and causes insulin resistance 

      Jang, Cholsoon; Oh, Sungwhan F; Wada, Shogo; Rowe, Glenn C; Liu, Laura; Chan, Mun Chun; Rhee, James; Hoshino, Atsushi; Kim, Boa; Ibrahim, Ayon; Baca, Luisa G; Kim, Esl; Ghosh, Chandra C; Parikh, Samir M; Jiang, Aihua; Chu, Qingwei; Forman, Daniel E.; Lecker, Stewart H.; Krishnaiah, Saikumari; Rabinowitz, Joshua D; Weljie, Aalim M; Baur, Joseph A; Kasper, Dennis L; Arany, Zoltan (2016)
      Epidemiological and experimental data implicate branched chain amino acids (BCAAs) in the development of insulin resistance, but the mechanisms underlying this link remain unclear.1–3 Insulin resistance in skeletal muscle ...

    • Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans 

      Parikh, Samir Mukund; Mammoto, Tadanori; Schultz, Aylit; Yuan, Hai-Tao; Christiani, David C.; Karumanchi, Subbian Ananth; Sukhatme, Vikas Pandurang (Public Library of Science, 2006)
      Background: Acute respiratory distress syndrome (ARDS) is a devastating complication of numerous underlying conditions, most notably sepsis. Although pathologic vascular leak has been implicated in the pathogenesis of ARDS ...

    • Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease) 

      Xie, Zhihui; Chan, Eunice; Yin, Yuzhi; Ghosh, Chandra C.; Wisch, Laura; Nelson, Celeste; Young, Michael; Parikh, Samir M.; Druey, Kirk M. (2014)
      Objectives: The Systemic Capillary Leak Syndrome (SCLS) is a rare and potentially fatal disorder resembling systemic anaphylaxis that is characterized by transient episodes of hypotensive shock and peripheral edema. The ...

    • PGC1α-dependent NAD biosynthesis links oxidative metabolism to renal protection 

      Tran, Mei T.; Zsengeller, Zsuzsanna K.; Berg, Anders H.; Khankin, Eliyahu V.; Bhasin, Manoj K.; Kim, Wondong; Clish, Clary B.; Stillman, Isaac E.; Karumanchi, S. Ananth; Rhee, Eugene P.; Parikh, Samir M. (2016)
      The energetic burden of continuously concentrating solutes against gradients along the tubule may render the kidney especially vulnerable to ischemia. Indeed, acute kidney injury (AKI) affects 3% of all hospitalized ...

    • The Synthetic Tie2 Agonist Peptide Vasculotide Protects Against Vascular Leakage and Reduces Mortality in Murine Abdominal Sepsis 

      Kümpers, Philipp; Gueler, Faikah; David, Sascha; Van Slyke, Paul; Dumont, Daniel J; Park, Joon-Keun; Bockmeyer, Clemens L; Pavenstädt, Hermann; Haller, Hermann; Shushakova, Nelli; Parikh, Samir Mukund (BioMed Central, 2011)
      Introduction: Angiopoietin-1 (Angpt1), the natural agonist ligand for the endothelial Tie2 receptor, is a non-redundant endothelial survival and vascular stabilization factor that reduces endothelial permeability and ...

    • Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Obstructive Sleep Apnea 

      Maski, Manish R.; Thomas, Robert J.; Karumanchi, S. Ananth; Parikh, Samir M. (Public Library of Science, 2016)
      Background: Obstructive sleep apnea (OSA) is a well-established risk factor for hypertension and cardiovascular morbidity and mortality. More recently, OSA has been implicated as an independent risk factor for chronic ...