Browsing by Author "Worby, Colin"
Now showing items 1-7 of 7
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The Distribution of Pairwise Genetic Distances: A Tool for Investigating Disease Transmission
Worby, Colin J.; Chang, Hsiao-Han; Hanage, William P.; Lipsitch, Marc (Genetics Society of America, 2014)Whole-genome sequencing of pathogens has recently been used to investigate disease outbreaks and is likely to play a growing role in real-time epidemiological studies. Methods to analyze high-resolution genomic data in ... -
Examining the role of different age groups, and of vaccination during the 2012 Minnesota pertussis outbreak
Worby, Colin J.; Kenyon, Cynthia; Lynfield, Ruth; Lipsitch, Marc; Goldstein, Edward (Nature Publishing Group, 2015)There is limited information on the roles of different age groups during pertussis outbreaks. Little is known about vaccine effectiveness against pertussis infection (both clinically apparent and subclinical), which is ... -
Impact of mupirocin resistance on the transmission and control of healthcare-associated MRSA
Deeny, Sarah R.; Worby, Colin J.; Tosas Auguet, Olga; Cooper, Ben S.; Edgeworth, Jonathan; Cookson, Barry; Robotham, Julie V. (Oxford University Press, 2015)Objectives: The objectives of this study were to estimate the relative transmissibility of mupirocin-resistant (MupR) and mupirocin-susceptible (MupS) MRSA strains and evaluate the long-term impact of MupR on MRSA control ... -
On the Relative Role of Different Age Groups During Epidemics Associated With Respiratory Syncytial Virus
Goldstein, Edward; Nguyen, Hieu H; Liu, Patrick; Viboud, Cecile; Steiner, Claudia A; Worby, Colin J; Lipsitch, Marc (Oxford University Press (OUP), 2017)Background While circulation of respiratory syncytial virus (RSV) results in high rates of hospitalization, particularly among young children and elderly individuals, little is known about the role of different age groups ... -
Population effect of influenza vaccination under co-circulation of non-vaccine variants and the case for a bivalent A/H3N2 vaccine component
Worby, Colin J; Wallinga, Jacco; Lipsitch, Marc; Goldstein, Edward (Elsevier BV, 2017) -
'SEEDY' (Simulation of Evolutionary and Epidemiological Dynamics): An R Package to Follow Accumulation of Within-Host Mutation in Pathogens
Worby, Colin J.; Read, Timothy D. (Public Library of Science, 2015)Genome sequencing is an increasingly common component of infectious disease outbreak investigations. However, the relationship between pathogen transmission and observed genetic data is complex, and dependent on several ... -
Within-Host Bacterial Diversity Hinders Accurate Reconstruction of Transmission Networks from Genomic Distance Data
Worby, Colin J.; Lipsitch, Marc; Hanage, William P. (Public Library of Science, 2014)The prospect of using whole genome sequence data to investigate bacterial disease outbreaks has been keenly anticipated in many quarters, and the large-scale collection and sequencing of isolates from cases is becoming ...