Browsing by Author "Adam, Rosalyn"

Now showing items 1-12 of 12

    • Acellular Bi-Layer Silk Fibroin Scaffolds Support Tissue Regeneration in a Rabbit Model of Onlay Urethroplasty 

      Chung, Yeun Goo; Tu, Duong; Franck, Debra; Gil, Eun Seok; Algarrahi, Khalid; Adam, Rosalyn M.; Kaplan, David L.; Estrada Jr., Carlos R.; Mauney, Joshua R. (Public Library of Science, 2014)
      Acellular scaffolds derived from Bombyx mori silk fibroin were investigated for their ability to support functional tissue regeneration in a rabbit model of urethra repair. A bi-layer silk fibroin matrix was fabricated by ...

    • All-Trans Retinoic Acid Directs Urothelial Specification of Murine Embryonic Stem Cells via GATA4/6 Signaling Mechanisms 

      Mauney, Joshua Robert; Ramachandran, Aruna; Yu, Richard N.; Daley, George Quentin; Adam, Rosalyn Mare; Estrada, Carlos R. (Public Library of Science, 2010)
      The urinary bladder and associated tract are lined by the urothelium, a transitional epithelium that acts as a specialized permeability barrier that protects the underlying tissue from urine via expression of a highly ...

    • DIAPH3 Governs the Cellular Transition to the Amoeboid Tumour Phenotype 

      Hager, Martin H; Morley, Samantha; Bielenberg, Diane R; Gao, Sizhen; Morello, Matteo; Holcomb, Ilona N; Liu, Wennuan; Mouneimne, Ghassan; Demichelis, Francesca; Kim, Jayoung; Solomon, Keith R; Adam, Rosalyn M; Isaacs, William B; Higgs, Henry N; Vessella, Robert L; Di Vizio, Dolores; Freeman, Michael R (WILEY-VCH Verlag, 2012)
      Therapies for most malignancies are generally ineffective once metastasis occurs. While tumour cells migrate through tissues using diverse strategies, the signalling networks controlling such behaviours in human tumours ...

    • Evaluation of Silk Biomaterials in Combination with Extracellular Matrix Coatings for Bladder Tissue Engineering with Primary and Pluripotent Cells 

      Franck, Debra; Gil, Eun Seok; Adam, Rosalyn Mare; Kaplan, David L.; Chung, Yeun Goo; Estrada, Carlos R.; Mauney, Joshua Robert (Public Library of Science, 2013)
      Silk-based biomaterials in combination with extracellular matrix (ECM) coatings were assessed as templates for cell-seeded bladder tissue engineering approaches. Two structurally diverse groups of silk scaffolds were ...

    • Fluidization and Resolidification of the Human Bladder Smooth Muscle Cell in Response to Transient Stretch 

      Rajendran, Kavitha; Deng, Linhong; Sokolov, Igor; Chen, Cheng; Krishnan, Ramaswamy; Zhou, Enhua; Ramachandran, Aruna; Tambe, Dhananjay T; Adam, Rosalyn Mare; Fredberg, Jeffrey J. (Public Library of Science, 2010)
      Background: Cells resident in certain hollow organs are subjected routinely to large transient stretches, including every adherent cell resident in lungs, heart, great vessels, gut, and bladder. We have shown recently that ...

    • The impact of discrete modes of spinal cord injury on bladder muscle contractility 

      Seth, Abhishek; Chung, Yeun Goo; Kim, Daniel; Ramachandran, Aruna; Cristofaro, Vivian; Gomez III, Pablo; Tu, Duong D; Huang, Lin; Benowitz, Larry Ira; Di Vizio, Dolores; Sullivan, Maryrose P.; Adam, Rosalyn Mare (BioMed Central, 2013)
      Background: Prior studies have compared the effect of spinal cord injury elicited using distinct approaches on motor and visceral function. However, the impact of such discrete modes of injury specifically on bladder muscle ...

    • Inhibition of TNF-α Improves the Bladder Dysfunction That Is Associated With Type 2 Diabetes 

      Wang, Zongwei; Cheng, Zhiyong; Cristofaro, Vivian; Li, Jijun; Xiao, Xingyuan; Gomez, Pablo; Ge, Rongbin; Gong, Edward; Strle, Klemen; Sullivan, Maryrose P.; Adam, Rosalyn M.; White, Morris F.; Olumi, Aria F. (American Diabetes Association, 2012)
      Diabetic bladder dysfunction (DBD) is common and affects 80% of diabetic patients. However, the molecular mechanisms underlying DBD remain elusive because of a lack of appropriate animal models. We demonstrate DBD in a ...

    • Inosine Improves Neurogenic Detrusor Overactivity following Spinal Cord Injury 

      Chung, Yeun Goo; Seth, Abhishek; Doyle, Claire; Franck, Debra; Kim, Daniel; Cristofaro, Vivian; Benowitz, Larry I.; Tu, Duong D.; Estrada, Carlos R.; Mauney, Joshua R.; Sullivan, Maryrose P.; Adam, Rosalyn M. (Public Library of Science, 2015)
      Neurogenic detrusor overactivity and the associated loss of bladder control are among the most challenging complications of spinal cord injury (SCI). Anticholinergic agents are the mainstay for medical treatment of detrusor ...

    • Integration of proteomic and transcriptomic profiles identifies a novel PDGF-MYC network in human smooth muscle cells 

      Yang, Wei; Ramachandran, Aruna; You, Sungyong; Jeong, HyoBin; Morley, Samantha; Mulone, Michelle D; Logvinenko, Tanya; Kim, Jayoung; Hwang, Daehee; Freeman, Michael R; Adam, Rosalyn M (BioMed Central, 2014)
      Background: Platelet-derived growth factor-BB (PDGF-BB) has been implicated in the proliferation, migration and synthetic activities of smooth muscle cells that characterize physiologic and pathologic tissue remodeling in ...

    • JunB Mediates Basal- and TGFβ1-Induced Smooth Muscle Cell Contractility 

      Ramachandran, Aruna; Gangopadhyay, Samudra Saurabh; Krishnan, Ramaswamy; Ranpura, Sandeep A.; Rajendran, Kavitha; Ram-Mohan, Sumati; Mulone, Michelle; Gong, Edward M.; Adam, Rosalyn Mare (Public Library of Science, 2013)
      Smooth muscle contraction is a dynamic process driven by acto-myosin interactions that are controlled by multiple regulatory proteins. Our studies have shown that members of the AP-1 transcription factor family control ...

    • Rapid Preparation of Nuclei-Depleted Detergent-Resistant Membrane Fractions Suitable for Proteomics Analysis 

      Adam, Rosalyn Mare; Yang, Wei; Di Vizio, Dolores; Mukhopadhyay, Nishit K.; Steen, Hanno (BioMed Central, 2008)
      Background: Cholesterol-rich membrane microdomains known as lipid rafts have been implicated in diverse physiologic processes including lipid transport and signal transduction. Lipid rafts were originally defined as ...

    • Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes 

      Morley, Samantha; You, Sungyong; Pollan, Sara; Choi, Jiyoung; Zhou, Bo; Hager, Martin H.; Steadman, Kenneth; Spinelli, Cristiana; Rajendran, Kavitha; Gertych, Arkadiusz; Kim, Jayoung; Adam, Rosalyn M.; Yang, Wei; Krishnan, Ramaswamy; Knudsen, Beatrice S.; Di Vizio, Dolores; Freeman, Michael R. (Nature Publishing Group, 2015)
      Taxanes are widely employed chemotherapies for patients with metastatic prostate and breast cancer. Here, we show that loss of Diaphanous-related formin-3 (DIAPH3), frequently associated with metastatic breast and prostate ...