Browsing by Author "Ter-Ovanesyan, Dmitry"

Now showing items 1-3 of 3

    • Cas9 gRNA Engineering for Genome Editing, Activation and Repression 

      Kiani, Samira; Chavez, Alejandro; Tuttle, Marcelle; Hall, Richard N; Chari, Raj; Ter-Ovanesyan, Dmitry; Qian, Jason; Pruitt, Benjamin W; Beal, Jacob; Vora, Suhani; Buchthal, Joanna; Kowal, Emma J K; Ebrahimkhani, Mohammad R; Collins, James; Weiss, Ron; Church, George (Springer Science and Business Media LLC, 2015-11)
      We demonstrate that by altering the length of Cas9-associated guide RNA(gRNA) we were able to control Cas9 nuclease activity and simultaneously perform genome editing and transcriptional regulation with a single Cas9 ...

    • Comparative Analysis of Cas9 Activators Across Multiple Species 

      Chavez, Alejandro; Tuttle, Marcelle; Pruitt, Benjamin W; Ewen-Campen, Ben; Chari, Raj; Ter-Ovanesyan, Dmitry; Haque, Sabina J; Cecchi, Ryan J; Kowal, Emma J K; Buchthal, Joanna; Housden, Benjamin E; Perrimon, Norbert; Collins, James J; Church, George (2016)
      Several groups have generated programmable transcription factors based on the versatile Cas9 protein, yet their relative potency and effectiveness across various cell types and species remain unexplored. Here, we compare ...

    • ISEV position paper: extracellular vesicle RNA analysis and bioinformatics 

      Hill, Andrew F.; Pegtel, D. Michiel; Lambertz, Ulrike; Leonardi, Tommaso; O'Driscoll, Lorraine; Pluchino, Stefano; Ter-Ovanesyan, Dmitry; Nolte-‘t Hoen, Esther N.M. (Co-Action Publishing, 2013)
      Extracellular vesicles (EVs) are the collective term for the various vesicles that are released by cells into the extracellular space. Such vesicles include exosomes and microvesicles, which vary by their size and/or protein ...