Browsing by Author "Zervantonakis, Ioannis"

Now showing items 1-5 of 5

    • Controlled electromechanical cell stimulation on-a-chip 

      Pavesi, Andrea; Adriani, Giulia; Rasponi, Marco; Zervantonakis, Ioannis K.; Fiore, Gianfranco B.; Kamm, Roger D. (Nature Publishing Group, 2015)
      Stem cell research has yielded promising advances in regenerative medicine, but standard assays generally lack the ability to combine different cell stimulations with rapid sample processing and precise fluid control. In ...

    • A Large Peptidome Dataset Improves HLA Class I Epitope Prediction Across Most of the Human Population 

      Le, Phuong M; Li, Letitia W; Oliveira, Giacomo; Keshishian, Hasmik; Hartigan, Christina R; Zhang, Wandi; Bachireddy, Pavan; Ouspenskaia, Tamara; Law, Travis; Justesen, Sune; Stevens, Jonathan; Eisenhaure, Thomas; Zhang, Guang Lan; Klauser, Karl R; Hacohen, Nir; Carr, Steven A; Sarkizova, Siranush; Klaeger, Susan; Braun, David; Ligon, Keith; Zervantonakis, Ioannis; Rosenbluth, Jennifer; Lane, William; Wu, Catherine; Keskin, Derin (Nature, 2019-12-16)
      Prediction of HLA epitopes is important for the development of cancer immunotherapies and vaccines. However, current prediction algorithms have limited predictive power, in part because they were not trained on high-quality ...

    • A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for β-catenin 

      Gallegos, Lisa Leon; Ng, Mei Rosa; Sowa, Mathew E.; Selfors, Laura M.; White, Anne; Zervantonakis, Ioannis K.; Singh, Pragya; Dhakal, Sabin; Harper, J. Wade; Brugge, Joan S. (Nature Publishing Group, 2016)
      Cell-cell adhesion is central to morphogenesis and maintenance of epithelial cell state. We previously identified 27 candidate cell-cell adhesion regulatory proteins (CCARPs) whose down-regulation disrupts epithelial ...

    • Registered report: Discovery and preclinical validation of drug indications using compendia of public gene expression data 

      Kandela, Irawati; Zervantonakis, Ioannis (eLife Sciences Publications, Ltd, 2015)
      The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and ...

    • Synergistic Effects of 3D ECM and Chemogradients on Neurite Outgrowth and Guidance: A Simple Modeling and Microfluidic Framework 

      Srinivasan, Parthasarathy; Zervantonakis, Ioannis K.; Kothapalli, Chandrasekhar R. (Public Library of Science, 2014)
      During nervous system development, numerous cues within the extracellular matrix microenvironment (ECM) guide the growing neurites along specific pathways to reach their intended targets. Neurite motility is controlled by ...