Browsing by Author "Scherrer-Crosbie, Marielle"

Now showing items 1-20 of 21

    • Assessment of Echocardiography and Biomarkers for the Extended Prediction of Cardiotoxicity in Patients Treated With Anthracyclines, Taxanes, and Trastuzumab 

      Sawaya, H.; Sebag, I. A.; Plana, J. C.; Januzzi, James Louis; Ky, B.; Tan, T. C.; Cohen, V.; Banchs, J.; Carver, J. R.; Wiegers, S. E.; Martin, R. P.; Picard, Michael Howard; Gerszten, Robert Edgardo; Halpern, E; Passeri, Jonathan James; Kuter, Irene; Scherrer-Crosbie, Marielle (Ovid Technologies (Wolters Kluwer Health), 2012)
      Background: Because cancer patients survive longer, the impact of cardiotoxicity associated with the use of cancer treatments escalates. The present study investigates whether early alterations of myocardial strain and ...

    • Brown Adipose Tissue Blood Flow and Mass in Obesity: A Contrast Ultrasound Study in Mice 

      Clerte, Maëva; Baron, David William; Brouckaert, Peter; Ernande, Laura; Raher, Michael J.; Flynn, Aidan W.; Picard, Michael Howard; Bloch, Kenneth; Buys, Emmanuel; Scherrer-Crosbie, Marielle (Elsevier BV, 2013)
      Background: When activated by the sympathetic nervous system, brown adipose tissue (BAT) increases energy expenditure to produce heat. Augmenting BAT mass or increasing BAT activation could potentially be used to decrease ...

    • Comparative Definitions for Moderate-Severe Ischemia in Stress Nuclear, Echocardiography, and Magnetic Resonance Imaging 

      Shaw, Leslee J.; Berman, Daniel S.; Picard, Michael Howard; Friedrich, Matthias G.; Kwong, Raymond Yan-Kit; Stone, Gregg W.; Senior, Roxy; Min, James K.; Hachamovitch, Rory; Scherrer-Crosbie, Marielle; Mieres, Jennifer H.; Marwick, Thomas H.; Phillips, Lawrence M.; Chaudhry, Farooq A.; Pellikka, Patricia A.; Slomka, Piotr; Arai, Andrew E.; Iskandrian, Ami E.; Bateman, Timothy M.; Heller, Gary V.; Miller, Todd D.; Nagel, Eike; Goyal, Abhinav; Borges-Neto, Salvador; Boden, William E.; Reynolds, Harmony R.; Hochman, Judith S.; Maron, David J.; Douglas, Pamela S. (Elsevier BV, 2014)
      The lack of standardized reporting of the magnitude of ischemia on noninvasive imaging contributes to variability in translating the severity of ischemia across stress imaging modalities. We identified the risk of coronary ...

    • Decreased Soluble Guanylate Cyclase Contributes to Cardiac Dysfunction Induced by Chronic Doxorubicin Treatment in Mice 

      Vandenwijngaert, Sara; Swinnen, Melissa; Walravens, Ann-Sophie; Beerens, Manu Eddy Maria; Gillijns, Hilde; Caluwé, Ellen; Tainsh, Robert; Nathan, Daniel I.; Allen, Kaitlin; Brouckaert, Peter; Bartunek, Jozef; Scherrer-Crosbie, Marielle; Bloch, Kenneth; Bloch, Donald Bendit; Janssens, Stefan P.; Buys, Emmanuel (Mary Ann Liebert Inc, 2017)
      Aims: The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of ...

    • Early Detection and Prediction of Cardiotoxicity in Chemotherapy-Treated Patients 

      Sawaya, Heloisa; Sebag, Igal A.; Plana, Juan Carlos; Januzzi, James Louis; Ky, Bonnie; Cohen, Victor; Gosavi, Sucheta; Carver, Joseph R.; Wiegers, Susan E.; Martin, Randolph P.; Picard, Michael Howard; Gerszten, Robert Edgardo; Halpern, Elkan; Passeri, Jonathan James; Kuter, Irene; Scherrer-Crosbie, Marielle (Elsevier BV, 2011)
      As breast cancer survival increases, cardiotoxicity associated with chemotherapeutic regimens such as anthracyclines and trastuzumab becomes a more significant issue. Assessment of the left ventricular (LV) ejection fraction ...

    • Early Increases in Multiple Biomarkers Predict Subsequent Cardiotoxicity in Patients With Breast Cancer Treated With Doxorubicin, Taxanes, and Trastuzumab 

      Ky, Bonnie; Putt, Mary; Sawaya, Heloisa; French, Benjamin; Januzzi, James Louis; Sebag, Igal A.; Plana, Juan Carlos; Cohen, Victor; Banchs, Jose; Carver, Joseph R.; Wiegers, Susan E.; Martin, Randolph P.; Picard, Michael Howard; Gerszten, Robert Edgardo; Halpern, Elkan; Passeri, Jonathan James; Kuter, Irene; Scherrer-Crosbie, Marielle (Elsevier BV, 2014)
      Objectives: The aim of this study was to determine if individual or multiple biomarkers are associated with cardiotoxicity in patients with breast cancer undergoing cancer therapy. Background: Current methods to identify ...

    • Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy 

      Thoonen, Robrecht; Ernande, Laura; Cheng, Juan; Nagasaka, Yasuko; Yao, Vincent; Miranda-Bezerra, Alexandre; Chen, Chan; Chao, Wei; Panagia, Marcello; Sosnovik, David E.; Puppala, Dheeraj; Armoundas, Antonis A.; Hindle, Allyson; Bloch, Kenneth; Buys, Emmanuel; Scherrer-Crosbie, Marielle (Elsevier BV, 2015)
      Brown adipose tissue (BAT) has well recognized thermogenic properties mediated by uncoupling protein 1 (UCP1); more recently, BAT has been demonstrated to modulate cardiovascular risk factors. To investigate whether BAT ...

    • In Vivo Noninvasive Characterization of Brown Adipose Tissue Blood Flow by Contrast Ultrasound in Mice 

      Baron, David M.; Clerte, Maeva; Brouckaert, Peter; Raher, Michael J.; Flynn, Aidan W.; Zhang, Haihua; Carter, Edward Albert; Picard, Michael Howard; Bloch, Kenneth Daniel; Buys, Emmanuel; Scherrer-Crosbie, Marielle (Ovid Technologies (Wolters Kluwer Health), 2012)
      Background—Interventions to increase brown adipose tissue (BAT) volume and activation are being extensively investigated as therapies to decrease the body weight in obese subjects. Noninvasive methods to monitor these ...

    • Innate Immune Adaptor MyD88 Mediates Neutrophil Recruitment and Myocardial Injury after Ischemia-Reperfusion in Mice 

      Feng, Yan; Zhao, Huailong; Xu, Xinhua; Buys, Emmanuel; Raher, Michael J.; Bopassa, Jean C.; Thibault, Helene; Scherrer-Crosbie, Marielle; Schmidt, Ulrich Hans; Chao, Wei (American Physiological Society, 2008)
      MyD88 is an adaptor protein critical for innate immune response against microbial infection and in certain noninfectious tissue injury. The present study examined the role of MyD88 in myocardial inflammation and injury ...

    • Lessons learned from MPI and physiologic testing in randomized trials of stable ischemic heart disease: COURAGE, BARI 2D, FAME, and ISCHEMIA 

      Phillips, Lawrence M.; Hachamovitch, Rory; Berman, Daniel S.; Iskandrian, Ami E.; Min, James K.; Picard, Michael Howard; Kwong, Raymond Yan-Kit; Friedrich, Matthias G.; Scherrer-Crosbie, Marielle; Hayes, Sean W.; Sharir, Tali; Gosselin, Gilbert; Mazzanti, Marco; Senior, Roxy; Beanlands, Rob; Smanio, Paola; Goyal, Abhi; Al-Mallah, Mouaz; Reynolds, Harmony; Stone, Gregg W.; Maron, David J.; Shaw, Leslee J. (Springer Science + Business Media, 2013)
      There is a preponderance of evidence that, in the setting of an acute coronary syndrome, an invasive approach using coronary revascularization has a morbidity and mortality benefit. However, recent stable ischemic heart ...

    • Longitudinal Changes in Multiple Biomarkers Are Associated with Cardiotoxicity in Breast Cancer Patients Treated with Doxorubicin, Taxanes, and Trastuzumab 

      Putt, M.; Hahn, V. S.; Januzzi, James Louis; Sawaya, H.; Sebag, I. A.; Plana, J. C.; Picard, Michael Howard; Carver, J. R.; Halpern, E; Kuter, Irene; Passeri, Jonathan James; Cohen, V.; Banchs, J.; Martin, R. P.; Gerszten, Robert Edgardo; Scherrer-Crosbie, Marielle; Ky, B. (American Association for Clinical Chemistry (AACC), 2015)
      BACKGROUND: Biomarkers may play an important role in identifying patients at risk for cancer therapy cardiotoxicity. Our objectives were to define the patterns of change in biomarkers with cancer therapy and their associations ...

    • Myocardial Alterations in Senescent Mice and Effect of Exercise Training: A Strain Rate Imaging Study 

      Derumeaux, G.; Ichinose, Fumito; Raher, M. J.; Morgan, J. G.; Coman, T.; Lee, C.; Cuesta, J. M.; Thibault, H.; Bloch, K. D.; Picard, Michael Howard; Scherrer-Crosbie, Marielle (Ovid Technologies (Wolters Kluwer Health), 2008)
      Background: Aging is accompanied by an alteration in myocardial contractility. However, its noninvasive detection is difficult. The effect of chronic exercise on this decrease is unknown. Murine models of senescence are ...

    • Nitric oxide synthase 3 deficiency limits adverse ventricular remodeling after pressure overload in insulin resistance 

      Kurtz, Baptiste; Thibault, Helene B.; Raher, Michael J.; Popovich, John R.; Cawley, Sharon; Atochin, Dmitriy N.; Hayton, Sarah; Shakartzi, Hannah R.; Huang, Paul Lee; Bloch, Kenneth Daniel; Buys, Emmanuel; Scherrer-Crosbie, Marielle (American Physiological Society, 2011)
      Insulin resistance (IR) and systemic hypertension are independently associated with heart failure. We reported previously that nitric oxide synthase 3 (NOS3) has a beneficial effect on left ventricular (LV) remodeling and ...

    • Phosphomimetic Modulation of eNOS Improves Myocardial Reperfusion and Mimics Cardiac Postconditioning in Mice 

      Pong, Terrence; Scherrer-Crosbie, Marielle; Atochin, Dmitriy N.; Bloch, Kenneth D.; Huang, Paul L. (Public Library of Science, 2014)
      Objective: Myocardial infarction resulting from ischemia-reperfusion injury can be reduced by cardiac postconditioning, in which blood flow is restored intermittently prior to full reperfusion. Although key molecular ...

    • Preload Dependency of Left Ventricular Torsion: The Impact of Normal Saline Infusion 

      Weiner, Rory Brett; Weyman, Arthur Edward; Khan, A. M.; Reingold, J. S.; Chen-Tournoux, A. A.; Scherrer-Crosbie, Marielle; Picard, Michael Howard; Wang, T. J.; Baggish, Aaron L. (Ovid Technologies (Wolters Kluwer Health), 2010)
      Background: Left ventricular (LV) rotation results from contraction of obliquely oriented myocardial fibers. The net difference between systolic apical counterclockwise rotation and basal clockwise rotation is left ventricular ...

    • sGC\(\alpha_1 \beta_1\) Attenuates Cardiac Dysfunction and Mortality in Murine Inflammatory Shock Models 

      Cauwels, Anje; Raher, Michael J; Rauwerdink, Kristen M; Thibault, Helene; Thoonen, Robrecht; Brouckaert, Peter; Buys, Emmanuel; Passeri, Jonathan James; Hobai, Ion; Cawley, Sharon M.; Sips, Patrick; Scherrer-Crosbie, Marielle; Ichinose, Fumito; Bloch, Kenneth Daniel (BioMed Central, 2009)

    • Soluble Guanylate Cyclase α1–Deficient Mice: A Novel Murine Model for Primary Open Angle Glaucoma 

      Ko, Yu-Chieh; Hayton, Sarah R.; Jones, Alexander; Tainsh, Laurel T.; Ren, Ruiyi; Giani, Andrea; Clerté, Maeva; Abernathy, Emma; de Waard, Nadine; Turcotte, Raphael; Nathan, Daniel; Loomis, Stephanie J.; Gong, Haiyan; Brouckaert, Peter; Buys, Emmanuel; Alt, Clemens; Tainsh, Robert Edward Tillinghast; Oh, Dong-Jin; Malhotra, Rajeev; Arora, Pankaj; Yu, Binglan; Scherrer-Crosbie, Marielle; Kang, Jae Hee Hee; Lin, Charles P.; Rhee, Douglas J; Wiggs, Janey Lee; Gregory, Meredith S.; Pasquale, Louis; Bloch, Kenneth Daniel; Ksander, Bruce R. (Public Library of Science, 2013)
      Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis of POAG remains unknown. Here, we report that mice lacking the \(α_1\) subunit of the nitric ...

    • Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. 

      Steudel, W; Scherrer-Crosbie, Marielle; Bloch, K D; Weimann, J; Huang, P L; Jones, R C; Picard, Michael Howard; Zapol, Warren Myron (American Society for Clinical Investigation, 1998)
      Chronic hypoxia induces pulmonary hypertension and right ventricular (RV) hypertrophy. Nitric oxide (NO) has been proposed to modulate the pulmonary vascular response to hypoxia. We investigated the effects of congenital ...

    • Validation of Noninvasive Measurements of Cardiac Output in Mice Using Echocardiography 

      Tournoux, François; Petersen, Bodil; Thibault, Hélène; Zou, Lin; Raher, Michael J.; Kurtz, Baptiste; Halpern, Elkan; Chaput, Miguel; Chao, Wei; Picard, Michael Howard; Scherrer-Crosbie, Marielle (Elsevier BV, 2011)
      Although multiple echocardiographic methods exist to calculate cardiac output (CO), they have not been validated in mice using a reference method. Echocardiographic and flow probe measurements of CO were obtained in mice ...

    • The value of core lab stress echocardiography interpretations: observations from the ISCHEMIA Trial 

      Kataoka, Akihisa; Scherrer-Crosbie, Marielle; Senior, Roxy; Gosselin, Gilbert; Phaneuf, Denis; Guzman, Gabriela; Perna, Gian; Lara, Alfonso; Kedev, Sasko; Mortara, Andrea; El-Hajjar, Mohammad; Shaw, Leslee J.; Reynolds, Harmony R.; Picard, Michael H. (BioMed Central, 2015)
      Background: Stress echocardiography (SE) is dependent on subjective interpretations. As a prelude to the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) Trial, potential ...