Browsing by Author "Serhan, Charles"
Now showing items 1-20 of 34
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Anti-angiogenesis Effect of the Novel Anti-inflammatory and Pro-resolving Lipid Mediators
Jin, Yiping; Arita, Makoto; Zhang, Qiang; Saban, Daniel R.; Chauhan, Sunil Kumar; Chiang, Nan; Serhan, Charles Nicholas; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2009)Purpose.Resolvins and lipoxins are lipid mediators generated from essential polyunsaturated fatty acids that are the first dual anti-inflammatory and pro-resolving signals identified in the resolution phase of inflammation. ... -
Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation
Abdulnour, Raja Elie E.; Sham, Ho Pan; Douda, David N.; Colas, Romain A.; Dalli, Jesmond; Bai, Yan; Ai, Xingbin; Serhan, Charles N.; Levy, Bruce D. (2016)Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Host responses to contain infection and mitigate pathogen-mediated lung inflammation are critical for pneumonia resolution. Aspirin-triggered ... -
Candida albicans Modulates Host Defense by Biosynthesizing the Pro-Resolving Mediator Resolvin E1
Haas-Stapleton, Eric J.; Lu, Yan; Hong, Song; Arita, Makoto; Favoreto, Silvio; Nigam, Santosh; Serhan, Charles Nicholas; Agabian, Nina (Public Library of Science, 2007)Candida albicans is an opportunistic fungal pathogen of humans that resides commensally on epithelial surfaces, but can cause inflammation when pathogenic. Resolvins are a class of anti-inflammatory lipids derived from ... -
Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators*
Tsoyi, Konstantin; Hall, Sean R. R.; Dalli, Jesmond; Colas, Romain A.; Ghanta, Sailaja; Ith, Bonna; Coronata, Anna; Fredenburgh, Laura E.; Baron, Rebecca M.; Choi, Augustine M. K.; Serhan, Charles N.; Liu, Xiaoli; Perrella, Mark A. (Lippincott Williams & Wilkins, 2016)Objectives: Mesenchymal stromal cells are being investigated as a cell-based therapy for a number of disease processes, with promising results in animal models of systemic inflammation and sepsis. Studies are ongoing to ... -
Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections
Dalli, Jesmond; Chiang, Nan; Serhan, Charles N. (2015)Endogenous mechanisms leading to host protection and resolution of infections without immunosuppression are of wide interest1,2. Here we elucidated the structures of four new host-protective molecules produced in ... -
Functional Metabolomics Reveals Novel Active Products in the DHA Metabolome
Shinohara, Masakazu; Mirakaj, Valbona; Serhan, Charles Nicholas (Frontiers Research Foundation, 2012)Endogenous mechanisms for successful resolution of an acute inflammatory response and the local return to homeostasis are of interest because excessive inflammation underlies many human diseases. In this review, we provide ... -
Human Milk Proresolving Mediators Stimulate Resolution of Acute Inflammation
Arnardottir, Hildur; Orr, Sarah K; Dalli, Jesmond; Serhan, Charles N (2015)Human milk contains nutrients and bioactive products relevant to infant development and immunological protection. Here, we investigated the pro-resolving properties of milk using human milk lipid mediator isolates (HLMI) ... -
Human Periodontal Stem Cells Release Specialized Proresolving Mediators and Carry Immunomodulatory and Prohealing Properties Regulated by Lipoxins
Cianci, Eleonora; Recchiuti, Antonio; Trubiani, Oriana; Diomede, Francesca; Marchisio, Marco; Miscia, Sebastiano; Colas, Romain A.; Dalli, Jesmond; Serhan, Charles N.; Romano, Mario (AlphaMed Press, 2016)Unresolved inflammation and tissue destruction are underlying mechanisms of periodontitis, which is linked to dysregulated polymorphonuclear neutrophil (PMN) functions. Lipoxin A4 (LXA4) is a specialized proresolving lipid ... -
Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3
Dalli, Jesmond; Sanger, Julia M.; Rodriguez, Ana R.; Chiang, Nan; Spur, Bernd W.; Serhan, Charles N. (Public Library of Science, 2016)Maresin conjugates in tissue regeneration (MCTR) are a new family of evolutionarily conserved chemical signals that orchestrate host responses to promote tissue regeneration and resolution of infections. Herein, we identified ... -
Identification of resolvin D2 receptor mediating resolution of infections and organ protection
Chiang, Nan; Dalli, Jesmond; Colas, Romain A.; Serhan, Charles N. (The Rockefeller University Press, 2015)Endogenous mechanisms that orchestrate resolution of acute inflammation are essential in host defense and the return to homeostasis. Resolvin (Rv)D2 is a potent immunoresolvent biosynthesized during active resolution that ... -
Infection Regulates Pro-Resolving Mediators that Lower Antibiotic Requirements
Chiang, Nan; Fredman, Gabrielle; Bäckhed, Fredrik; Oh, Sungwhan; Vickery, Thad; Schmidt, Birgitta A R; Serhan, Charles Nicholas (2012)Underlying mechanisms for how bacterial infections contribute to active resolution of acute inflammation are unknown. Here, we performed exudate leukocyte trafficking and mediator-metabololipidomics of murine peritoneal ... -
Lipid Mediators in Innate Immunity Against Tuberculosis: Opposing Roles of PGE2 and LXA4 in the Induction of Macrophage Death
Chen, Minjian; Divangahi, Maziar; Gan, Huixian; Shin, Daniel S.J.; Hong, Song; Lee, David Marvin; Serhan, Charles Nicholas; Behar, Samuel M; Remold, Heinz G (Rockefeller University Press, 2008)Virulent Mycobacterium tuberculosis (Mtb) induces a maladaptive cytolytic death modality, necrosis, which is advantageous for the pathogen. We report that necrosis of macrophages infected with the virulent Mtb strains H37Rv ... -
Lipoxin A4 activates ALX/FPR2 Receptor to Regulate Conjunctival Goblet Cell Secretion
Hodges, Robin R.; Li, Dayu; Shatos, Marie A.; Bair, Jeffrey A.; Lippestad, Marit; Serhan, Charles N.; Dartt, Darlene A. (2016)Conjunctival goblet cells play a major role in maintaining the mucous layer of the tear film under physiological conditions as well as in inflammatory diseases like dry eye and allergic conjunctivitis.. Resolution of ... -
Lipoxin A4 Counter-regulates Histamine-stimulated Glycoconjugate Secretion in Conjunctival Goblet Cells
Hodges, Robin R.; Li, Dayu; Shatos, Marie A.; Serhan, Charles N.; Dartt, Darlene A. (Nature Publishing Group, 2016)Conjunctival goblet cells synthesize and secrete mucins which play an important role in protecting the ocular surface. Pro-resolution mediators, such as lipoxin A4 (LXA4), are produced during inflammation returning the ... -
Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and Pro-Resolving Mediator from Human Macrophages
Deng, Bin; Wang, Chin-Wei; Arnardottir, Hildur H.; Li, Yongsheng; Cheng, Chien-Yee Cindy; Dalli, Jesmond; Serhan, Charles N. (Public Library of Science, 2014)Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages. Here we identified a novel pro-resolving product, 13R,14S-dihydroxy-docosahexaenoic ... -
A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae
Ramirez, Jose Luis; de Almeida Oliveira, Giselle; Calvo, Eric; Dalli, Jesmond; Colas, Romain A.; Serhan, Charles N.; Ribeiro, Jose M.; Barillas-Mury, Carolina (Nature Pub. Group, 2015)Exposure of Anopheles gambiae mosquitoes to Plasmodium infection enhances the ability of their immune system to respond to subsequent infections. However, the molecular mechanism that allows the insect innate immune system ... -
Native and Aspirin-Triggered Lipoxins Control Innate Immunity by Inducing Proteasomal Degradation of TRAF6
Machado, Fabiana S.; Esper, Lísia; Dias, Alexandra; Madan, Rajat; Gu, YuanYuan; Hildeman, David; Serhan, Charles Nicholas; Karp, Christopher L.; Aliberti, Júlio (The Rockefeller University Press, 2008)Innate immune signaling is critical for the development of protective immunity. Such signaling is, perforce, tightly controlled. Lipoxins (LXs) are eicosanoid mediators that play key counterregulatory roles during infection. ... -
New Lives Given by Cell Death: Macrophage Differentiation Following Their Encounter with Apoptotic Leukocytes during the Resolution of Inflammation
Ariel, Amiram; Serhan, Charles Nicholas (Frontiers Research Foundation, 2012)Monocytes that migrate into tissues during inflammatory episodes and differentiate to macrophages were previously classified as classically (M1) or alternatively (M2) activated macrophages, based on their exposure to ... -
A Novel Anti-Inflammatory and Pro-Resolving Role for Resolvin D1 in Acute Cigarette Smoke-Induced Lung Inflammation
Hsiao, Hsi-Min; Sapinoro, Ramil E.; Thatcher, Thomas H.; Croasdell, Amanda; Levy, Elizabeth P.; Fulton, Robert A.; Olsen, Keith C.; Pollock, Stephen J.; Serhan, Charles Nicholas; Phipps, Richard P.; Sime, Patricia J. (Public Library of Science, 2013)Introduction: Cigarette smoke is a profound pro-inflammatory stimulus that contributes to acute lung injuries and to chronic lung disease including COPD (emphysema and chronic bronchitis). Until recently, it was assumed ... -
Novel n-3 Immunoresolvents: Structures and Actions
Dalli, Jesmond; Colas, Romain A.; Serhan, Charles N. (Nature Publishing Group, 2013)Resolution of inflammation is now held to be an active process where autacoids promote homeostasis. Using functional-metabololipidomics and in vivo systems, herein we report that endogenous n-3 docosapentaenoic (DPA) acid ...