Browsing by Author "Cho, Hansang"

Now showing items 1-3 of 3

    • Microfluidic Chemotaxis Platform for Differentiating the Roles of Soluble and Bound Amyloid-β on Microglial Accumulation 

      Cho, Hansang; Hashimoto, Tadafumi; Wong, Elisabeth; Hori, Yukiko; Wood, Levi Benjamin; Zhao, Lingzhi; Haigis, Kevin M; Hyman, Bradley Theodore; Irimia, Daniel (Nature Publishing Group, 2013)
      Progressive microglial accumulation at amyloid-β (Aβ) plaques is a well-established signature of the pathology of Alzheimer's disease, but how and why microglia accumulate in the vicinity of Aβ plaques is unknown. To ...

    • Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain 

      Takeda, Shuko; Wegmann, Susanne; Cho, Hansang; DeVos, Sarah L.; Commins, Caitlin; Roe, Allyson D.; Nicholls, Samantha B.; Carlson, George A.; Pitstick, Rose; Nobuhara, Chloe K.; Costantino, Isabel; Frosch, Matthew P.; Müller, Daniel J.; Irimia, Daniel; Hyman, Bradley T. (Nature Pub. Group, 2015)
      Tau pathology is known to spread in a hierarchical pattern in Alzheimer's disease (AD) brain during disease progression, likely by trans-synaptic tau transfer between neurons. However, the tau species involved in inter-neuron ...

    • Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology 

      Cho, Hansang; Seo, Ji Hae; Wong, Keith H. K.; Terasaki, Yasukazu; Park, Joseph; Bong, Kiwan; Arai, Ken; Lo, Eng H.; Irimia, Daniel (Nature Publishing Group, 2015)
      Blood–brain barrier (BBB) pathology leads to neurovascular disorders and is an important target for therapies. However, the study of BBB pathology is difficult in the absence of models that are simple and relevant. In vivo ...