Browsing by Author "Smith, Lois"

Now showing items 1-20 of 39

    • Altered Cholesterol Homeostasis in Aged Macrophages Linked to Neovascular Macular Degeneration 

      Chen, Jing; Smith, Lois Elaine Hodgson (Elsevier BV, 2013)
      Abnormal lipid metabolism has been linked to age-related macular degeneration (AMD); choroidal neovascularization in late AMD commonly causes blindness. Sene et al. (2013) now demonstrate that in aged macrophages decreased ...

    • The Biology of Retinopathy of Prematurity 

      Smith, Lois Elaine Hodgson; Hard, Anna-Lena; Hellström, Ann (Elsevier BV, 2013)
      Retinopathy of prematurity occurs because the retina of a preterm infant at birth is incompletely vascularized, and if the postnatal environment does not match the in utero environment that supported retinal development, ...

    • Choroid Sprouting Assay: An Ex Vivo Model of Microvascular Angiogenesis 

      Shao, Zhuo; Friedlander, Mollie; Hurst, Christian G.; Cui, Zhenghao; Pei, Dorothy T.; Evans, Lucy P.; Juan, Aimee M.; Tahir, Houda; Duhamel, François; Chen, Jing; Sapieha, Przemyslaw; Chemtob, Sylvain; Joyal, Jean-Sébastien; Smith, Lois E. H. (Public Library of Science, 2013)
      Angiogenesis of the microvasculature is central to the etiology of many diseases including proliferative retinopathy, age-related macular degeneration and cancer. A mouse model of microvascular angiogenesis would be very ...

    • Current update on retinopathy of prematurity: screening and treatment 

      Chen, Jing; Stahl, Andreas; Hellstrom, Ann; Smith, Lois Elaine Hodgson (Ovid Technologies (Wolters Kluwer Health), 2011)
      PURPOSE OF REVIEW: Despite current treatments, retinopathy of prematurity (ROP) remains a major cause of blindness in premature infants and the incidence is increasing with increased survival of infants born at very early ...

    • Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. 

      Shao, Zhuo; Fu, Zhong Jie; Stahl, A.; Joyal, Julie Anne; Hatton, Colin Paul; Juan, A.; Hurst, C.; Evans, L.; Cui, Z.; Pei, D.; Gong, Yan; Xu, D.; Tian, K.; Bogardus, H.; Edin, M. L.; Lih, F.; Sapieha, P.; Chen, Jing; Panigrahy, Dipak; Hellstrom, A.; Zeldin, D. C.; Smith, Lois Elaine Hodgson (Ovid Technologies (Wolters Kluwer Health), 2014)
      OBJECTIVE: Regulation of angiogenesis is critical for many diseases. Specifically, pathological retinal neovascularization, a major cause of blindness, is suppressed with dietary ω3-long-chain polyunsaturated fatty acids ...

    • DNA Sequence Variants in PPARGC1A, a Gene Encoding a Coactivator of the ω-3 LCPUFA Sensing PPAR-RXR Transcription Complex, Are Associated with NV AMD and AMD-Associated Loci in Genes of Complement and VEGF Signaling Pathways 

      SanGiovanni, John Paul; Chen, Jing; Sapieha, Przemyslaw; Aderman, Christopher; Stahl, Andreas; Clemons, Traci E.; Chew, Emily Y.; Smith, Lois Elaine Hodgson (Public Library of Science (PLoS), 2013)
      BACKGROUND: Increased intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFAs) and use of peroxisome proliferator activator receptor (PPAR)-activating drugs are associated with attenuation of pathologic retinal ...

    • Effect of Preterm Birth on Postnatal Apolipoprotein and Adipocytokine Profiles 

      Hellgren, Gunnel; Engstrom, Eva; Smith, Lois Elaine Hodgson; Löfqvist, Chatarina; Hellström, Ann (S. Karger AG, 2015)
      BACKGROUND: Critical metabolic changes preparing for ex utero life may occur at the fetal age of approximately 28-32 weeks, and preterm birth <28 weeks postmenstrual age (PMA) may affect these pathways. Children born <28 ...

    • Ghrelin Modulates Physiologic and Pathologic Retinal Angiogenesis through GHSR-1a 

      Zaniolo, Karine; Sapieha, Przemyslaw; Shao, Zhuo; Stahl, Andreas; Zhu, Tang; Tremblay, Sophie; Picard, Emilie; Madaan, Ankush; Blais, Martine; Lachapelle, Pierre; Mancini, Joseph; Hardy, Pierre; Smith, Lois Elaine Hodgson; Ong, Huy; Chemtob, Sylvain (Association for Research in Vision and Ophthalmology (ARVO), 2011)
      PURPOSE: Vascular degeneration and the ensuing abnormal vascular proliferation are central to proliferative retinopathies. Given the metabolic discordance associated with these diseases, the authors explored the role of ...

    • Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis 

      Srinivasan, Srimathi; Chitalia, Vipul; Meyer, Rosana D.; Hartsough, Edward; Mehta, Manisha; Harrold, Itrat; Anderson, Nicole; Feng, Hui; Smith, Lois Elaine Hodgson; Jiang, Yan; Costello, Catherine E.; Rahimi, Nader (Springer Science + Business Media, 2015)
      Expression and activation of vascular endothelial growth factor receptor 2 (VEGFR-2) by VEGF ligands are the main events in the stimulation of pathological angiogenesis. VEGFR-2 expression is generally low in the healthy ...

    • Importance of Early Postnatal Weight Gain for Normal Retinal Angiogenesis in Very Preterm Infants 

      Wu, Carolyn S.; Löfqvist, Chatarina; Smith, Lois Elaine Hodgson; Vanderveen, Deborah K.; Hellström, Ann (American Medical Association (AMA), 2012)
      OBJECTIVE: To assess WINROP (https://winrop.com), an algorithm using postnatal weight measurements, as a tool for the prediction of retinopathy of prematurity (ROP) in a large geographically and racially diverse study ...

    • Insulin-Like Growth Factor-1 and Anti-Vascular Endothelial Growth Factor in Retinopathy of Prematurity: Has the Time Come 

      Stahl, Andreas; Hellstrom, Ann; Smith, Lois Elaine Hodgson (S. Karger AG, 2014)
      Treatment of ROP is currently evolving. Novel therapeutic options are emerging that have the potential to complement existing therapies and improve treatment outcomes. However, any new therapeutic options must be thoroughly ...

    • Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development 

      Hellström, Ann; Ley, David; Hansen‐Pupp, Ingrid; Hallberg, Boubou; Löfqvist, Chatarina; van Marter, Linda; van Weissenbruch, Mirjam; Ramenghi, Luca A.; Beardsall, Kathryn; Dunger, David; Hård, Anna‐Lena; Smith, Lois E. H. (John Wiley and Sons Inc., 2016)
      Abstract Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin‐like growth factor 1 (IGF‐1) axis is the major hormonal mediator of ...

    • Lipid metabolites in the pathogenesis and treatment of neovascular eye disease 

      Stahl, A; Krohne, T. U.; Sapieha, P.; Chen, Jing; Hellstrom, A.; Chew, E.; Holz, F. G.; Smith, Lois Elaine Hodgson (BMJ, 2011)
      Lipids and lipid metabolites have long been known to play biological roles that go beyond energy storage and membrane structure. In age-related macular degeneration and diabetes, for example, dysregulation of lipid metabolism ...

    • Longitudinal infusion of a complex of insulin-like growth factor-I and IGF-binding protein-3 in five preterm infants: pharmacokinetics and short-term safety 

      Ley, David; Hansen-Pupp, Ingrid; Niklasson, Aimon; Domellöf, Magnus; Friberg, Lena E.; Borg, Jan; Löfqvist, Chatarina; Hellgren, Gunnel; Smith, Lois Elaine Hodgson; Hård, Anna-Lena; Hellström, Ann (Nature Publishing Group, 2012)
      BACKGROUND: In preterm infants, low levels of insulin-like growth factor-I (IGF-I) and IGF binding protein 3 (IGFBP-3) are associated with impaired brain growth and retinopathy of prematurity (ROP). Treatment with IGF-I/IGFBP-3 ...

    • Low Birth Weight Is a Risk Factor for Severe Retinopathy of Prematurity Depending on Gestational Age 

      Lundgren, Pia; Kistner, Anna; Andersson, Eva M.; Hansen Pupp, Ingrid; Holmström, Gerd; Ley, David; Niklasson, Aimon; Smith, Lois E. H.; Wu, Carolyn; Hellström, Ann; Löfqvist, Chatarina (Public Library of Science, 2014)
      Objective: To evaluate the impact of low birth weight as a risk factor for retinopathy of prematurity (ROP) that will require treatment in correlation with gestational age at birth (GA). Study design In total, 2941 infants ...

    • LRP5 Regulates Development of Lung Microvessels and Alveoli through the Angiopoietin-Tie2 Pathway 

      Mammoto, Tadanori; Jiang, Amanda Rose; Jiang, Elizabeth Qingyu; Mammoto, Akiko; Chen, Jing; Smith, Lois Elaine Hodgson; Ingber, Donald Elliott (Public Library of Science, 2012)
      Angiogenesis is crucial for lung development. Although there has been considerable exploration, the mechanism by which lung vascular and alveolar formation is controlled is still not completely understood. Here we show ...

    • A Mechanosensitive Transcriptional Mechanism That Controls Angiogenesis 

      Mammoto, Akiko; Connor, Kip; Mammoto, Tadanori; Yung, Chong W.; Huh, Dongeun; Aderman, Christopher Michael; Mostoslavsky, Gustavo; Smith, Lois Elaine Hodgson; Ingber, Donald Elliott (Nature Publishing Group, 2009)
      Angiogenesis is controlled by physical interactions between cells and extracellular matrix as well as soluble angiogenic factors, such as VEGF. However, the mechanism by which mechanical signals integrate with other ...

    • Netrin-1 – DCC Signaling Systems and Age-Related Macular Degeneration 

      SanGiovanni, John Paul; Chen, Jing; Gupta, Ankur S.; Smith, Lois E. H.; Sapieha, Przemyslaw; Lee, Phil H. (Public Library of Science, 2015)
      We conducted a nested candidate gene study and pathway-based enrichment analysis on data from a multi-national 77,000-person project on the molecular genetics of age-related macular degeneration (AMD) to identify AMD-associated ...

    • Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy 

      Chen, Jing; Michan, Shaday; Juan, Aimee M.; Hurst, Christian G.; Hatton, Colman J.; Pei, Dorothy T.; Joyal, Jean-Sebastien; Evans, Lucy P.; Cui, Zhenghao; Stahl, Andreas; Sapieha, Przemyslaw; Sinclair, David Andrew; Smith, Lois Elaine Hodgson (Springer Science + Business Media, 2013)
      Regeneration of blood vessels in ischemic neuronal tissue is critical to reduce tissue damage in diseases. In proliferative retinopathy, initial vessel loss leads to retinal ischemia, which can induce either regrowth of ...

    • Nutrition, insulin-like growth factor-1 and retinopathy of prematurity 

      Hård, Anna-Lena; Smith, Lois Elaine Hodgson; Hellström, Ann (Elsevier BV, 2013)
      Retinopathy of prematurity is a potentially blinding disease starting with impaired retinal vessel growth in the neonatal period. Weeks to months later, peripheral retinal hypoxia induces pathologic neovascularization that ...