Browsing by Author "Murphy, George"

Now showing items 1-19 of 19

    • 5-Hydroxymethylcytosine Expression in Metastatic Melanoma versus Nodal Nevus in Sentine Lymph Node Biopsies 

      Lee, Jonathan J.; Granter, Scott R.; Laga, Alvaro C.; Saavedra, Arturo; Zhan, Qian; Guo, Weimin; Xu, Shuyun; Murphy, George F.; Lian, Christine G. (2014)
      Sentinel lymph node biopsies are conducted to stage patients with newly-diagnosed melanomas that have histopathologic attributes conferring defined levels of metastatic potential. Because benign nevic cells may also form ...

    • Angiogenesis in Wounds Treated by Microdeformational Wound Therapy 

      Erba, Paolo; Ogawa, Rei; Ackermann, Maximilian; Adini, Avner; Miele, Lino F.; Dastouri, Pouya; Helm, Douglas; Mentzer, Steven James; D’Amato, Robert J.; Murphy, George Francis; Konerding, Moritz A.; Orgill, Dennis Paul (Ovid Technologies (Wolters Kluwer Health), 2011)
      Background: Mechanical forces play an important role in tissue neovascularization and are a constituent part of modern wound therapies. The mechanisms by which vacuum assisted closure (VAC) modulates wound angiogenesis are ...

    • Diagnostic Immunohistochemistry in Cutaneous Neoplasia: An Update 

      Compton, Leigh A.; Murphy, George F.; Lian, Christine G. (S. Karger AG, 2015)
      Immunohistochemistry (IHC) is an important adjunct in the diagnosis of neoplastic skin diseases. In addition to the many established IHC markers currently in use, new markers continue to emerge, although their general ...

    • Disruption of TNFα/TNFR1 function in resident skin cells impairs host immune response against cutaneous vaccinia virus infection 

      Tian, Tian; Dubin, Krista; Jin, Qiushuang; Qureshi, Ali; King, Sandra L.; Liu, Luzheng; Jiang, Xiaodong; Murphy, George F.; Kupper, Thomas S.; Fuhlbrigge, Robert C. (2012)
      One strategy adopted by vaccinia virus (VV) to evade the host immune system is to encode homologs of TNF receptors (TNFR) that block TNFα function. The response to VV skin infection under conditions of TNFα deficiency, ...

    • The Effect of Hydrostatic Pressure on Three-Dimensional Chondroinduction of Human Adipose–Derived Stem Cells 

      Ogawa, Rei; Mizuno, Shuichi; Murphy, George Francis; Orgill, Dennis Paul (Mary Ann Liebert Inc, 2009)
      Background: The optimal production of three-dimensional cartilage in vitro requires both inductive factors and specified culture conditions (e.g., hydrostatic pressure [HP], gas concentration, and nutrient supply) to promote ...

    • Evaluation of stromal HGF immunoreactivity as a biomarker for melanoma response to RAF inhibitors 

      Lezcano, Cecilia; Lee, Chung-Wei; Larson, Allison R.; Menzies, Alexander M.; Kefford, Richard F.; Thompson, John F.; Mihm, Martin C.; Ogino, Shuji; Long, Georgina V.; Scolyer, Richard A.; Murphy, George F. (2013)
      Of more than 150,000 published studies evaluating new biomarkers, fewer than 100 biomarkers have been implemented for patient care[1]. One reason for this is lack of rigorous testing by the medical community to validate ...

    • Immunity to the Melanoma Inhibitor of Apoptosis Protein (ML-IAP; livin) in Patients with Malignant Melanoma 

      Zhou, Jun; Yuen, Noah K.; Zhan, Qian; Velazquez, Elsa F.; Murphy, George Francis; Giobbie-Hurder, Anita; Hodi, Frank Stephen (Springer-Verlag, 2011)
      Therapeutic targeting of melanoma antigens frequently focuses on the melanocyte differentiation or cancer-testis families. Antigen-loss variants can often result, as these antigens are not critical for tumor cell survival. ...

    • Inhibition of Angiogenesis by Tissue Inhibitor of Metalloproteinase-3 

      Olsen, Bjorn; Zetter, Bruce; Apte, S; Murphy, George; Montesano, R; Pepper, M; Voest, E; Anand-Apte, B (Association for Research in Vision and Ophthalmology, 1997-04)
      PURPOSE: It has been established that Sorsby's fundus dystrophy, a dominantly inherited form of blindness, is caused by mutations in the tissue inhibitor of metalloproteinase-3 (TIMP-3) gene. Because choroidal neovascularization ...

    • Keloids and Hypertrophic Scars: Update and Future Directions 

      Huang, Chenyu; Murphy, George F.; Akaishi, Satoshi; Ogawa, Rei (Wolters Kluwer Health, 2013)
      Summary: The development of cutaneous pathological scars, namely, hypertrophic scars (HSs) and keloids, involves complex pathways, and the exact mechanisms by which they are initiated, evolved, and regulated remain to be ...

    • Leukotriene B4-Driven Neutrophil Recruitment to the Skin Is Essential for Allergic Skin Inflammation 

      Oyoshi, Michiko K.; He, Rui; Li, Yitang; Mondal, Subhanjan; Yoon, Juhan; Afshar, Roshi; Chen, Mei; Lee, David M.; Luo, Hongbo; Luster, Andrew David; Cho, John S.; Miller, Lloyd S.; Larson, Allison; Murphy, George Francis; Geha, Raif Salim (Elsevier BV, 2012)
      Scratching triggers skin flares in atopic dermatitis. We demonstrate that scratching of human skin and tape stripping of mouse skin cause neutrophil influx. In mice, this influx was largely dependent on the generation of ...

    • Loss of 5-hydroxymethylcytosine correlates with increasing morphologic dysplasia in melanocytic tumors 

      Larson, Allison R.; Dresser, Karen; Zhan, Qian; Lezcano, Cecilia; Woda, Bruce A.; Yosufi, Benafsha; Thompson, John F.; Scolyer, Richard A.; Mihm, Martin C.; Shi, Yujiang G.; Murphy, George F.; Lian, Christine Guo (2013)
      DNA methylation is the most well studied epigenetic modification in cancer biology. 5-hydroxymethylcytosine is an epigenetic mark that can be converted from 5-methylcytosine by the ten-eleven translocation gene family. We ...

    • Loss of the epigenetic mark, 5-Hydroxymethylcytosine, correlates with small cell/nevoid subpopulations and assists in microstaging of human melanoma 

      Lee, Jonathan J.; Cook, Martin; Mihm, Martin C.; Xu, Shuyun; Zhan, Qian; Wang, Thomas J.; Murphy, George F.; Lian, Christine G. (Impact Journals LLC, 2015)
      Melanomas in the vertical growth phase (VGP) not infrequently demonstrate cellular heterogeneity. One commonly encountered subpopulation displays small cell/nevoid morphology. Although its significance remains unknown, ...

    • Merkel Cell Carcinoma Expresses Vasculogenic Mimicry: Demonstration in Patients and Experimental Manipulation in Xenografts 

      Lezcano, Cecilia; Kleffel, Sonja; Lee, Nayoung; Larson, Allison R.; Zhan, Qian; DoRosario, Andrew; Wang, Linda C.; Schatton, Tobias; Murphy, George F. (2014)
      Merkel cell carcinoma (MCC) is a highly virulent cutaneous neoplasm that, like melanoma, is a frequent cause of patient morbidity and mortality. The cellular mechanisms responsible for the aggressive behavior of MCC remain ...

    • Microdeformation of Three-Dimensional Cultured Fibroblasts Induces Gene Expression and Morphological Changes 

      Lu, Feng; Ogawa, Rei; Nguyen, Dinh T.; Chen, Bin; Guo, Danfeng; Helm, Douglas; Zhan, Qian; Murphy, George Francis; Orgill, Dennis Paul (Ovid Technologies (Wolters Kluwer Health), 2011)
      Background: Vacuum-assisted closure induces microdeformations of the wound surface and accelerates healing of complex wounds; however, a thorough understanding of the biology of cellular mechanotransduction is lacking. We ...

    • Nestin depletion induces melanoma matrix metalloproteinases and invasion 

      Lee, Chung-Wei; Zhan, Qian; Lezcano, Cecilia; Frank, Markus H.; Huang, John; Larson, Allison; Lin, Jennifer Y.; Wan, Marilyn T.; Lin, Ping-I; Ma, Jie; Kleffel, Sonja; Schatton, Tobias; Lian, Christine G.; Murphy, George F. (2015)
      Matrix metalloproteinases (MMPs) are key biological mediators of processes as diverse as wound healing, embryogenesis, and cancer progression. Although MMPs may be induced through multiple signaling pathways, the precise ...

    • NOD2 Regulates Hematopoietic Cell Function During Graft-versus-host Disease 

      Penack, Olaf; Smith, Odette M.; Cunningham-Bussel, Amy; Rao, Uttam; Yim, Nury; Na, Il-Kang; Holland, Amanda M.; Ghosh, Arnab; Lu, Sydney X.; Jenq, Robert R.; Brandl, Katharina; van den Brink, Marcel R.M.; Liu, Xin; Liu, Chen; Murphy, George Francis (The Rockefeller University Press, 2009)
      Nucleotide-binding oligomerization domain 2 (NOD2) polymorphisms are independent risk factors for Crohn's disease and graft-versus-host disease (GVHD). In Crohn's disease, the proinflammatory state resulting from NOD2 ...

    • Novel Genetic Mutations in a Sporadic Port-Wine Stain 

      Lian, Christine Guo; Sholl, Lynette Marie; Zakka, Labib; O, Teresa M.; Liu, Cynthia; Xu, Shuyun; Stanek, Ewelina; Garcia, Elizabeth; Jia, Yonghui; MacConaill, Laura Eleanor; Murphy, George Francis; Waner, Milton; Mihm, Martin Charles (American Medical Association (AMA), 2014)
      Importance Port-wine stains (PWSs) are common congenital cutaneous capillary malformations. A somatic GNAQ mutation was recently identified in patients with sporadic PWSs and Sturge-Weber syndrome. However, subsequent ...

    • Synthesis and characterization of a model extracellular matrix that induces partial regeneration of adult mammalian skin. 

      Yannas, I. V.; Lee, Edward Y.; Orgill, Dennis Paul; Skrabut, E. M.; Murphy, George Francis (Proceedings of the National Academy of Sciences, 1989)
      Regeneration of the dermis does not occur spontaneously in the adult mammal. The epidermis is regenerated spontaneously provided there is a dermal substrate over which it can migrate. Certain highly porous, crosslinked ...

    • Use of the parabiotic model in studies of cutaneous wound healing to define the participation of circulating cells 

      Song, Guodong; Nguyen, Dinh T.; Pietramaggiori, Giorgio; Scherer, Saja; Chen, Bing; Zhan, Qian; Ogawa, Rei; Yannas, I.V.; Wagers, Amy Jo; Orgill, Dennis Paul; Murphy, George Francis (Wiley-Blackwell, 2010)
      Previous experimental studies to assess the contribution of blood-borne circulating (BBC) cells to cutaneous wound healing have relied on discontinuous pulsing of labeled BBC elements or bone marrow transplant protocols. ...